Category: 610-93-5

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,610-93-5

(a) 3-Hydroxy-6-nitro-1(3H)-isobenzofuranone (3a) A mixture of 6-nitro-1(3H)-isobenzofuranone (8.99 g, 50.0 mmol) and N-bromosuccinimide (8.9 g, 50.0 mmol) in carbon tetrachloride (135 mL) was stirred and heated under reflux for one hour during which time the reaction mixture was exposed to the light from a 275 Watt, 125 Volt Hanovia sunlamp that was situated 8 inches from the flask. After cooling, the succinimide was removed by filtration, and the filtrate was evaporated in vacuo. The oily residue was mixed with water (200 mL), and the mixture was refluxed for one hour to give a clear, colorless solution. On cooling, the Compound 3a crystallized from solution. An analytical sample was prepared by recrystallization from water; m.p. 157-160 C.; IR 3390 cm-1 (OH), 1770 cm-1 (C=O), 1 H NMR (CDCl3 -Me2 SO-d6 -D2 O) delta6.78 (s, br, 1H, H3), 7.88 (d, 1H, H4, J4,5 =9 Hz), 8.56 (d, 1H, H5, J=9 Hz), 8.62 (s, 1H, H6). Anal. Calcd. for C8 H5 NO5: C, 49.24; H, 2.58; N, 7.18; Found: C, 49.39; H, 2.58; N, 7.13.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4591587; (1986); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

610-93-5, 6-Nitrophthalide (20 mmol) was dissolved in ethyl acetate (200 mL) and methanol (50 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.3 g). After 18 h the reaction mmixture was filtered through a bed of celite and the filtrate was removed under reduced pressure. The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide.5

The synthetic route of 610-93-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1269 – 1273;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,610-93-5

(a) 6-Nitrophthalide (14.0 g; J A Houbion, J A Miles and J A Paton, Organic Preparations and Procedures International, 11 (1), 27, 1979) in solution in acetic acid was hydrogenated over a palladium on carbon catalyst to give 6-aminophthalide (12.0 g; W R Vaughan and S L Baird, J. Amer. Chem. Soc. 68, 1314, 1946).

The synthetic route of 610-93-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ICI Australia Limited; US4409017; (1983); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

610-93-5, General procedure: The catalytic reduction of nitro aromatics was conducted in a 25 mlTelfon-lined stainless steel autoclave with magnetic stirring. In a typicalprocess, 6 mmol nitroarene, and desired amounts of reducing agent andsolvents were introduced in the reactor. The autoclave was transferredinto a water bath at the set temperature with an accuracy of better than0.2 C for ?0.5 h. Then, 10 mg catalyst was added into the reactionmixture and started the reduction at a stirring rate of 450 rpm. After thereaction, the catalyst was rapidly separated by ltration. n-Decane(500 muL) as standard was added into the ltrate and was dried withanhydrous Na 2 SO 4 . The products were analyzed by gas chromato-graphy-mass spectrometry (GC-MS) (Shimadzu GCMS-QP2010 Plus)and GC (Varian CP-3800) with a capillary column (column VF-1 ms,15 m, 0.25 mm, 0.25 mum) and a ame ionization detector (FID).

As the paragraph descriping shows that 610-93-5 is playing an increasingly important role.

Reference£º
Article; Huang, Haigen; Liang, Xiangcheng; Wang, Xueguang; Sheng, Yao; Chen, Chenju; Zou, Xiujing; Lu, Xionggang; Applied Catalysis A: General; vol. 559; (2018); p. 127 – 137;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

610-93-5, A mixture of compounds 12 (10 mmol) and 10% (mass fraction) Pd/C (0.20 g) in MeOH (20 mL) was subjected to standard hydrogenolysis condition at atmospheric pressure (balloon) and room temperature. The progress of the reaction was monitored by TLC. After completion of the reactions, the reaction mixture was filtered off and the filtrate was evaporated on a rotary evaporator to afford the crude products 13, which were used directly in the next step without further purification. Yield: 87%, Mp: 186-187 C. 1H-NMR (CDCl3, 600 MHz), d: 7.28(s, 1H, ArH), 7.11-7.07(m, 1H, ArH), 7.05(dd, J = 8.1Hz, 2.1Hz, 1H, ArH), 5.25(s, 2H), 3.95(s, 2H, NH2). 5110 X. Hu et al. 123

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Hu, Xia-min; Cui, Zhi-wen; Dong, Wei; Zhu, Yue; Gao, Cheng-zhi; Xu, Shi-qiang; Yuan, Qiong; Yu, Zhi-jun; Min, Zhen-li; Research on Chemical Intermediates; vol. 44; 9; (2018); p. 5107 – 5122;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

610-93-5, 6-Nitrophthalide (10 mmol) was dissolved in ethyl acetate (100 mL) and methanol (25 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.2 g). After 24 h the reaction mixture was filtered through a bed of celite and the filtrate was removed under reduced pressure.The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide. 6-Hydroxyphthalide was synthesized by reacting a cold suspension of 6-aminophthalide (3 mmol) in 10 mL H2SO4 (50%) with a cold solution of NaNO2 (3.5 mmol in 3 mL H2O) to yield the diazonium salt. The resulting solution was added to boiling (125 C) H2SO4 (50%, 20 mL) and the reaction mixture was boiled for 5 min. The reaction was rapidly cooled in an ice bath, and subsequently extracted to diethyl ether (3×20 mL). The ether portions were combined, washed with a saturated solution of NaHCO3 (25 mL) and dried over anhydrous Na2SO4. The ether was removed under reduced pressure, leaving the brown 6-hydroxyphthalide residue. Yield 65%; m.p. 198-200 C; 1H NMR (300MHz, DMSO) delta 5.25 (s, 2H), 7.15-7.18 (m, 2H), 7.39 (d, J=9.0 Hz, 1H); ESI-MS m/z: 150.9 [M+H]+.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Zhimin; Wu, Jiajia; Yang, Xuelian; Cai, Pei; Liu, Qiaohong; Wang, Kelvin D.G.; Kong, Lingyi; Wang, Xiaobing; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5929 – 5940;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,610-93-5

General procedure: To a screw top vial (5 mL) under N2 containing freshly distilled toluene (0.6 mL) were successively added an aromatic nitro compound (0.60 mmol), InI3 (14.9 mg, 0.030 mmol), and TMDS (318 muL, 1.80 mmol). After the vial was sealed with a cap that contained a PTFE septum, the mixture was stirred at 60 C (bath temperature), and monitored via TLC analysis. Sat. aq NaHCO3 solution (5 mL) was added to the resultant mixture, which was then extracted with EtOAc (3 ¡Á 6 mL). The combined organic phases were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (n-hexane-EtOAc, 9:1 to 4:1) to afford the corresponding aniline derivative.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Sakai, Norio; Asama, Shun; Konakahara, Takeo; Ogiwara, Yohei; Synthesis; vol. 47; 20; (2015); p. 3179 – 3185;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem