Day: October 21, 2020

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Salicylaldehyde (IIe, 1.06mL, 10mmol) was added to a stirred solution of benzofuranone (III, 1.34g, 10mmol) in CH2Cl2 under an argon atmosphere at room temperature. The mixture was then allowed to react for 5min. Aluminum Oxide (2g) was then added and the reaction was carried out at room temperature for 3h. The reaction was stirred for 30min until precipitation occurred. The mixture was filtered, washed with ethyl acetate, and dried to yield 1.57g (6.6mmol, 66.0%) as an orange solid., 7169-34-8

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kadayat, Tara Man; Banskota, Suhrid; Gurung, Pallavi; Bist, Ganesh; Thapa Magar, Til Bahadur; Shrestha, Aarajana; Kim, Jung-Ae; Lee, Eung-Seok; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 575 – 597;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 11 (0.414 g, 2 mmol), dichloromethane (5 mL), DMF (0.1 mL) was added to the reaction flask,(0.519 g, 6 mmol) oxalyl chloride. The reaction solution was allowed to stand at room temperature for 2 hours and concentrated. The residue was dissolved in acetone at 0 C, and then concentrated aqueous ammonia (7.5 mL) was added dropwise. The mixture was stirred for 10 minutes. A large amount of water was added to the reaction solution to precipitate a solid, And dried to give 0.28 g of compound 12 in a yield of 68%., 10242-12-3

Big data shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; Luoyang Juhui Pharmaceutical Technology Co., Ltd.; Zhang Hongli; Yang Songfeng; (36 pag.)CN106749203; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

90843-31-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a stirred solution of 1-(2,3-dihydro-benzofuran-5-yl)-ethanone (2.5 g, 15.4 mmol) (Lancaster) in dioxane (20 mL) was added dropwise a solution of bromine (2.96 g, 18.5 mmol) in dioxane (60 mL). After stirring 15 minute the mixture was concentrated in vacuo and the residue was purified by chromatography on silica gel (2:1 hexane-dichloromethane) to provide 1.41 g (38%) of 2-bromo-1-(2,3-dihydro-benzofuran-5-yl)-ethanone.

90843-31-5 5-Acetyl-2,3-dihydrobenzo[b]furan 145220, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright; US2004/6058; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 15 10.9 g. of 6-hydroxy-2,3-dihydrobenzofuran are dissolved in 80 ml. of anhydrous dimethylformamide and treated, while stirring and with ice cooling at 0¡ã C. with 5.3 g. of freshly powdered potassium hydroxide. The mixture is stirred for 1 hour at 0¡ã C. under a nitrogen atmosphere and then added dropwise within 1 hour to a solution of 19.6 g. of 1-bromo-7-ethyl-3-methyl-2,6-nonadiene in 10 ml. of absolute tetrahydrofuran. The mixture is allowed to stir for 2 hours at 0¡ã C. and for 2 hours at room temperature and then poured onto a mixture of 100 ml. of 10percent by weight aqueous sodium hydroxide and 100 ml. of ice-water. The mixture is extracted three times with pentane, the extracts are washed successively with 10percent by weight aqueous sodium hydroxide, water and saturated sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (19:1 parts by volume) there is obtained pure 6-[(7-ethyl-3-methyl-2,6-nonadienyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 132¡ã C./0.02 mmHg; nD20 = 1.5350., 23681-89-2

The synthetic route of 23681-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a solution of 5-bromobenzofuran (3.9 g, 20 mmol) in dry THF (30 mL) cooled to -78C under N2-protected LDA (prepared from n-BuLi and /Pr2NH in THF (-30 mmol)) was slowly added. The mixture was stirred at the same temperature for 30 minutes, then triz’wpropylborate (5.64 g, 30 mmol) was added to the mixture. The mixture was allowed to warm to RT and stirred for 2 hours. The mixture was then quenched with IN HCl to pH=3 and extracted with EtOAc. The combined organic phases were combined, dried and filtered. The filtrate was concentrated to afford the desired product (4.3 g). MS (ESI) m/e (M+Ff1): 241., 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; COBURN, Craig, A.; MCCAULEY, John, A.; LUDMERER, Steven, W.; LIU, Kun; VACCA, Joseph, P.; WU, Hao; HU, Bin; SOLL, Richard; SUN, Fei; WANG, Xinghai; YAN, Man; ZHANG, Chengren; ZHENG, Mingwei; ZHONG, Bin; ZHU, Jian; WO2010/111483; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

37418-88-5, 4-Hydroxyisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 4-hydroxyisobenzofuran-1,3-dione (1.2 g, 7.3 mmol) in pyridine (25 mL) was added 3-aminopiperidine-2,6-dione-TFA salt (1.8 g, 7.3 mmol) at room temperature. The resulting reaction mixture was then warmed to 110 C. and stirred for 16 h. The reaction mixture was then evaporated under reduced pressure. The crude product was purified using silica gel column chromatography (4% MeOH-DCM) to give 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione as yellow solid (1 g, 50%). LC-MS (ESI) m/z 273.2 (M-H)+., 37418-88-5

37418-88-5 4-Hydroxyisobenzofuran-1,3-dione 96580, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

EXAMPLE 4 Preparation of 2,3-dihydrobenzofuran-5-sulfonyl chloride Sulfur trioxide-N,N-dimethylformamide complex (9.2 g, 60 mmoles) and N,N-dimethylformamide (20 ml) were added to a 250 ml, 3-necked flask under nitrogen purge. The solution was stirred at room temperature and 2,3-dihydrobenzofuran (6.0 g, 50 mmoles) was added dropwise. The solution was slowly heated to 85¡ã-90¡ã C. over the course of one hour. The light brown solution was allowed to come to room temperature and thionyl chloride (7.2 g, 60 mmoles) was added dropwise. The mixture was allowed to stir one hour at room temperature. The solution was slowly heated to 85¡ã C. and was maintained at that temperature for 1 hour. The solution was allowed to cool to 40¡ã C. Toluene (25 ml) was added to the solution, which was then poured into a mixture of ice and water (50 ml). Another 25 ml aliquot of toluene was added. The mixture was stirred for 10 minutes to dissolve any solids and the layers were separated. The aqueous layer was extracted with toluene (3*25 ml). The combined toluene layers were washed with water and dried over magnesium sulfate. The magnesium sulfate was removed and washed with toluene. The toluene was removed under vacuum, leaving 10.0 g of the title product (91.7percent yield). Nuclear magnetic resonance assays confirmed the identity of the title compound. FDMS (MeOH) m/e 218 (M+). Analysis for C8 H7 ClO3 S: Theory: C, 43.94; H, 3.23. Found: C, 44.14; H, 3.24., 496-16-2

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US5387681; (1995); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product., 87-41-2

As the paragraph descriping shows that 87-41-2 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28281-76-7,5-Methoxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

28281-76-7, EXAMPLE 158 N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-4-methoxyphthalimide A stirred mixture of 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethylamine (2.63 g, 0.01 mole) and 4-methoxyphthalic anhydride (1.78 g, 0.01 mole) in dichloromethane (100 ml) is stirred at room temperature for 3 hours. The solvent is then removed under reduced pressure and the residual material is purified by flash chromatography. The product is purified further by recrystallization to give N-[2-[4-(6-fluoro-1,2-benzisoxazol-3yl)-1-piperidinyl]ethyl]-4-methoxyphthalimide.

The synthetic route of 28281-76-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals, Inc.; US5364866; (1994); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

58546-89-7, To a solution of benzofuran-5-amine (CAS No. 58546-89-7, 200 mg, 1.5 mmol) in acetic acid (8 mL) was added ammonium thiocyanate (456 mg, 6.0 mmol) at RT under nitrogen atmosphere. After stirring for 10 min, bromine (480 mg, 3.0 mmol) was added dropwise at about 10 C. The resulting mixture was slowly warmed to RT and stirred for 12 h. The precipitate was collected by filtration to afford the title compound as pale brown solid (200 mg, 70%). LC/MS (ES+) calcd for C9H6N2OS: 190.0; found: 193.0 [M+3]. 1H NMR (400 MHz, DMSO-d6): delta 8.01 (d, J=2.0 Hz, 1H), 7.46 (d, J=8.4 Hz, 1H), 7.36 (s, 2H), 7.32 (d, J=8.4 Hz, 1H), 6.99 (d, J=2.0 Hz, 1H).

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

Reference£º
Patent; Kineta Immuno-Oncology LLC; Goldberg, Daniel R.; Probst, Peter; Bedard, Kristin M.; (72 pag.)US2020/55871; (2020); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem