Category: 7169-34-8

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7169-34-8, General procedure: Coumaranone (1.00mmol) and aldehyde (1.00mmol) were combined in a dry vial. 3.5g of neutral alumina was then added followed by 5ml of dichloromethane. The reaction mixture was stirred for 12h at 25C. The reaction mixture was then filtered and the dichloromethane layer collected and concentrated to dryness in vacuo. Further purification was performed as noted.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Park, Hyo S.; Nelson, David E.; Taylor, Zachary E.; Hayes, James B.; Cunningham, Kirsten D.; Arivett, Brock A.; Ghosh, Rajarshi; Wolf, Larissa C.; Taylor, Kimberley M.; Farone, Mary B.; Handy, Scott T.; Farone, Anthony L; International Immunopharmacology; vol. 43; (2017); p. 116 – 128;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7169-34-8, General procedure: In the following syntheses, coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a microwave vial. 1 mL of the deep eutectic solvent formed from a 1:2 molar ratio of choline chloride and urea was added. The tube was then microwaved at 90 C for 30 minutes. At this point, the reaction was allowed to cool to room temperature and partitioned between water and methylene chloride. The organic layer was separated and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Taylor, Kimberly M.; Taylor, Zachary E.; Handy, Scott T.; Tetrahedron Letters; vol. 58; 3; (2017); p. 240 – 241;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of benzofuran-3(2H)-one (134mg, 1mmol) in dry methanol (20mL) at room temperature was added the appropriate aldehyde (1.2mmol) and Al2O3 (1mmol). The mixture was refluxed, under N2, for 48h. After, the solvent was removed and the solid residue was dissolved in CH2Cl2. The organic layer was washed with water, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 523 – 534;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.,7169-34-8

General procedure: To a solution of benzofuran-3(2H)-one derivative (2a,b,d, 1.2 mmol) in ethanol (5 ml) in the presence of corresponding benzaldehyde (1.3 mmol), aqueous solution of 5% HCl (1 ml) was added and the mixture was refluxed for 6-9 hours (controlled by TLC). After cooling in an ice bath, the solution was neutralized by adding a cold solution of 2% KOH to reach the pH of 5-6. The resulting yellow precipitate was filtered and recrystallized from diluted methanol to give the desired products.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Roshanzamir, Khashayar; Kashani-Amin, Elaheh; Ebrahim-Habibi, Azadeh; Navidpour, Latifeh; Letters in drug design and discovery; vol. 16; 3; (2019); p. 333 – 340;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7169-34-8

General procedure: To a solution of benzofuran-3(2H)-one (134mg, 1mmol) in dry methanol (20mL) at room temperature was added the appropriate aldehyde (1.2mmol) and Al2O3 (1mmol). The mixture was refluxed, under N2, for 48h. After, the solvent was removed and the solid residue was dissolved in CH2Cl2. The organic layer was washed with water, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product.

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 523 – 534;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

7169-34-8, General procedure: To a solution of benzofuran-3(2H)-one (1.0 mmol) and benzaldehyde(1.0 mmol) in dichloromethane (6 mL) was added aluminum oxide (30.0 mmol) at room temperature. After stirring for 6 h, the reaction mixture was filtered off. The filtrate was concentrated under vacuum and the residue was purified by flash chromatography on silica gel to give the desired compound

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Sheng; Xu, Lei; Lu, Yu-Ting; Liu, Yu-Fei; Han, Bing; Liu, Ting; Tang, Jie; Li, Jia; Wu, Jiangping; Li, Jing-Ya; Yu, Li-Fang; Yang, Fan; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 195 – 208;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Salicylaldehyde (IIe, 1.06mL, 10mmol) was added to a stirred solution of benzofuranone (III, 1.34g, 10mmol) in CH2Cl2 under an argon atmosphere at room temperature. The mixture was then allowed to react for 5min. Aluminum Oxide (2g) was then added and the reaction was carried out at room temperature for 3h. The reaction was stirred for 30min until precipitation occurred. The mixture was filtered, washed with ethyl acetate, and dried to yield 1.57g (6.6mmol, 66.0%) as an orange solid., 7169-34-8

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kadayat, Tara Man; Banskota, Suhrid; Gurung, Pallavi; Bist, Ganesh; Thapa Magar, Til Bahadur; Shrestha, Aarajana; Kim, Jung-Ae; Lee, Eung-Seok; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 575 – 597;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.,7169-34-8

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product. (Z)-2-Benzylidenebenzofuran-3(2H)-one (4a). Pale yellow color solid (380 mg, 86%), mp 102-104 C (lit.23 mp110-111 C). 1H NMR (CDCl3): 7.93 (2H, d, J 6.8 Hz), 7.82 (1H, d, J 7.6 Hz), 7.66 (1H, t, J 8.2 Hz), 7.38-7.48 (3H,m), 7.34 (1H, d, J 8.0 Hz), 7.22 (1H, t, J 7.4 Hz), 6.90 (1H, s); 13C NMR (CDCl3): 184.7, 166.2, 146.9, 136.8, 132.4,131.5, 129.9, 128.9, 124.7, 123.5, 121.7, 113.0, 112.9; LC-MS (positive ion mode): m/z 223 (M+H)+.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7169-34-8

General procedure: A mixture of 7-substituted 3(2H)-benzofuranones (7a and 7b) (1 eq), substituted aromatic aldehydes (8a-d)(1 eq), in ethanol (10 mL) were added 3 drops of piperidine. The mixture was then heated under reflux for 2 hours. After cooling H2O (20 mL) was added slowly. The crystalline precipitate was separated by filtration and purified by recrystallization from ethanol to afford pure compounds (9a-g).

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Paidakula, Suresh; Nerella, Srinivas; Vadde, Ravinder; Kamal; Kankala, Shravankumar; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2153 – 2156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

7169-34-8, General procedure: Coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a dry vial. 3.5 g of neutral alumina was then added followed by 5 mL of dichloromethane. The reaction mixture was stirred for 12 h at 25 C. The reaction mixture was then filtered and the dichloromethane layer collected and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sutton, Caleb L.; Taylor, Zachary E.; Farone, Mary B.; Handy, Scott T.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 901 – 903;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem