7169-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.
General procedure: To a solution of benzofuran-3(2H)-one (134mg, 1mmol) in dry methanol (20mL) at room temperature was added the appropriate aldehyde (1.2mmol) and Al2O3 (1mmol). The mixture was refluxed, under N2, for 48h. After, the solvent was removed and the solid residue was dissolved in CH2Cl2. The organic layer was washed with water, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product.
7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Article; Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 523 – 534;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem