With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.
Method B To an ice-cooled solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) (0.33 g, 2.0 mmol) in 3 ml of acetic acid there was added dropwise 0.6 ml of HNO3. The mixture was stirred in a warm oil bath (70C) for 24 hours, and then poured into water. After cooling, the product was collected on a filter to give 0.21 g of solid (50.2%). This was recrystallized from ethyl acetate to afford 0.14 g (33.5%) of 15k , mp 249-251.5C., 35700-40-4
35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem