With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.
58546-89-7, To a solution of benzofuran-5-amine (CAS No. 58546-89-7, 200 mg, 1.5 mmol) in acetic acid (8 mL) was added ammonium thiocyanate (456 mg, 6.0 mmol) at RT under nitrogen atmosphere. After stirring for 10 min, bromine (480 mg, 3.0 mmol) was added dropwise at about 10 C. The resulting mixture was slowly warmed to RT and stirred for 12 h. The precipitate was collected by filtration to afford the title compound as pale brown solid (200 mg, 70%). LC/MS (ES+) calcd for C9H6N2OS: 190.0; found: 193.0 [M+3]. 1H NMR (400 MHz, DMSO-d6): delta 8.01 (d, J=2.0 Hz, 1H), 7.46 (d, J=8.4 Hz, 1H), 7.36 (s, 2H), 7.32 (d, J=8.4 Hz, 1H), 6.99 (d, J=2.0 Hz, 1H).
As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.
Reference£º
Patent; Kineta Immuno-Oncology LLC; Goldberg, Daniel R.; Probst, Peter; Bedard, Kristin M.; (72 pag.)US2020/55871; (2020); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem