With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42933-43-7,2,3-Dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.
2,3-dihydro-benzofuran-5-amine (1A) (5.7 g, 42.20 mmol) was added to hydrochloric acid (10.2 mL, 12N) water (25 mL) was cooled to -5 ¡ã C to 0 ¡ã C, solution of sodium nitrite (3.2 g, 46.4 mmol) in water (20 mL) solution, after the addition was complete, 0 ¡ã C for 30 minutes to obtain a diazonium salt solution, standby; then sodium acetate (7.9 g , 97.1 mmol) in water (25 ml) with 1-chloro-1- (methylsulfonyl) propyl-2-one (7.2g, 42.2 mmol) in ethyl acetate (70 mL) mixed solution, maintaining 0 ¡ã C, the diazonium salt solution was slowly alternate dropwise added to the mixture, after the addition was complete, the reaction at room temperature for 4 hours. The reaction solution was extracted stratification, the organic phase dried over anhydrous sodium sulfate, and concentrated under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether (v / v) = l: 4) to give the title compound Nu-(2,3-dihydrobenzofuran-5-yl)-1-methylsulfonylmethanehydrazonoyl chloride (12B) as a yellow solid (1.3 g, yield 11.2percent).
42933-43-7, The synthetic route of 42933-43-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
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