77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
77095-51-3, Add HATU (418 mg, 1.1 mmol) and DIPEA (390 mg, 3 mmol) to a vigorously stirred solution of benzofuran-6-carboxylic acid (178 mg, 1.1 mmol) in DMF (5 mL). After the reaction mixture was reacted at room temperature for 1 hour, (S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]-quinazoline-7-carbonylamino)- 3-(3-(Methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate (649 mg, 1 mmol), the mixture was stirred at room temperature for 2 hours. Ethyl acetate was added (100 mL), sequentially washed with water (20mL), saturated brine (20mL) was washed, and the organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated, the residue was purified by flash chromatography, Petroleum ether with 50% ethyl acetate in hexanes to afford the desired product as a white solid (661mg, 0.95mmol 95%).
The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Weimou Bio-technology (Shanghai) Co., Ltd.; Shen Wang; Ding Yue; Wang Jiangfeng; Jiang Hao; Chen Fuli; Wu Xinglong; Li Cunfei; Yang Liguo; Hu Biao; (34 pag.)CN109721605; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem