With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
2,2-Diphenyl-2-pyrrolidin-3-yl-acetamide (2, 2.8 g, 0.01 mol) and 5-(2-bromoethyl)-2,3-dihydrobenzofuran (3, 4.54 g, 0.02 mol) were refluxed in acetone (70 mL) containing K2CO3 (2.76 g, 0.02 mol). After completion of the reaction mass was concentrated under vacuum and the obtained residue was poured into water. The separated solid was filtered and dried. The crude product was purified over silica gel column using MDC: MeOH (99:1 to 96:4) as eluent to obtain product in 4 g yield. IR (KBr): 3220, 3056, 2946, 2856, 1698, 1614, 1491, 1443, 1359, 1243, 1219, 1101, 1076, 814, 752,701 cm-1; 1H MNR (300 MHz, CDCl3): delta 0.68 (m, 1H), 1.40-1.44 (m, 1H), 2.41-2.61 (m, 2H), 2.41-2.61 (m, 2H), 2.75-3.16 (m, 1H), 2.78 (m, 1H), 3.08 (t, J=8.6 Hz, 2H), 3.20-3.25 (m, 1H), 3.23-3.60 (m, 1H), 3.38-3.43 (m, 1H), 4.44 (t, J=8.9 Hz, 2H), 6.62 (d, J=8.1 Hz, 1H), 6.84 (d, J=8.1 Hz, 1H), 6.90 (d, J=6.9 Hz, 4H), 6.98 (s, 1H), 7.20-7.33 (m, 2H), 7.40 (d, J=6.6 Hz, 4H), 8.15 (brs, 1H); 13C NMR (75 MHz, CDCl3): delta 27.55, 29.06, 32.22, 40.06, 43.41, 50.94, 70.58, 108.36, 125.16, 126.33, 126.51, 126.96, 127.46, 127.69, 127.77, 128.55, 132.13, 141.18, 141.73, 157.81, 176.85; DIP MS: m/z (percent) 573 [M+H]+ (100). Anal. Calcd for C38H40N2O3: C, 79.69; H, 7.04; N, 4.89. Found: C, 79.48; H, 7.10; N, 4.79percent., 127264-14-6
The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem