With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79002-39-4,Benzofuran-5-carbonitrile,as a common compound, the synthetic route is as follows.
79002-39-4, EXAMPLE 20 Preparation of 1-benzofuran-5-carbaldehyde To a solution of 1-benzofuran-5-carbonitrile (5.0 g, 34.9 mmol) in CH2Cl2 under nitrogen at -15 to -20 C. was added DIBAL-H (41.9 mL, 41.9 mmol, 1 M/heptane) and the temperature was maintained below -15 C. After addition was complete, the reaction mixture was stirred at -15 to -20 C. for an additional 10 min. The reaction mixture was quenched via dropwise addition of aqueous 2N HCl. The organic layer was separated and washed with water, dried over sodium sulfate, and concentrated to give 4.0 g (78%) of 1-benzofuran-5-carbaldehyde as a yellow oil.
The synthetic route of 79002-39-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Cole, Derek Cecil; Asselin, Magda; Boschelli, Diane Harris; Wissner, Allan; Wang, Yanong Daniel; Prashad, Amarnauth Shastrie; Dushin, Russell; US2007/287738; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem