Category: 50551-63-8

Tanemura, Kiyoshi published the artcileThe reaction of 2,3-dichloro-5,6-dicyano-p-benzoquinone with benzofurans and indoles, SDS of cas: 50551-63-8, the main research area is dichlorodicyanobenzoquinone addition benzofuran indole.

The reaction of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) with 6-methoxy-3-methylbenzofuran gave carbon-oxygen adduct I. The reaction in less polar solvents such as benzene and CH2Cl2 proceeds faster than that in more polar solvents such as THF and dioxane. In contrast, the reaction of DDQ with indoles II (R1 = H, Cl, Br, OMe, R2 = H; R1 = H, R2 = Me) gave carbon-carbon adducts III. This reaction proceeds rapidly with increasing solvent polarity.

Bulletin of the Chemical Society of Japan published new progress about dichlorodicyanobenzoquinone addition benzofuran indole. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, SDS of cas: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Okuyama, Tadashi published the artcileSubstituent effects in the benzofuran system. III. Cationic polymerization, Recommanded Product: 6-Methoxybenzofuran, the main research area is benzofuran polymerization substituent effect.

Cationic copolymerization of pairs of benzofuran derivatives have been carried out in CH2Cl2 using SnCl4-CCl3CO2H (2:1) as catalyst at 0°. Effects of 2- and 3-Me substitutions on the monomer reactivity ratio suggested that the polymeric cation added at the 2-C of benzofuran. Anal. of the effects of 5- and 6-substituents on the reactivity revealed that the transmission efficiency of electronic effects through the two paths, the bonds 8-3 and 9-1-2, was comparable in magnitude. The transition state of the propagation step resembled a bridged carbonium ion intermediate.

Bulletin of the Chemical Society of Japan published new progress about Polymerization. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Song, Shu-Yong published the artcileAn improved and scale-up synthesis of 6-hydroxybenzofuran, Synthetic Route of 50551-63-8, the main research area is hydroxybenzofuran green synthesis scale up.

An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.

Research on Chemical Intermediates published new progress about Green chemistry. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Synthetic Route of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Martin-Santamaria, Sonsoles published the artcileNew scaffolds for the design of selective estrogen receptor modulators, Recommanded Product: 6-Methoxybenzofuran, the main research area is estrogen receptor modulator antitumor pancreatic cancer.

In the present work we report the synthesis of four new ER ligands which can be used as scaffolds for the introduction of the basic side chains necessary for antiestrogenic activity. Affinities and agonist/antagonist characterization of the ligands for both ERα and ERβ have been determined in a competitive radioligand assay, and in an in vitro coactivator recruitment functional assay, resp. Mol. modeling techniques have been used in order to rationalize the exptl. results. Compound 2 is reported as a novel ERβ-agonist/ERα-antagonist. Two compounds show an interesting antitumor profile towards two pancreatic cancer cell lines and have been selected for in vivo assays.

Organic & Biomolecular Chemistry published new progress about Antitumor agents. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fabian, Walter published the artcileInterpretation of the influence of substituents on the UV spectra of benzofurans, Application In Synthesis of 50551-63-8, the main research area is UV benzofuran derivative substituent effect.

The electronic excitation energies of 12 isometric methoxy- and nitrobenzofuran were calculated by means of PPP and CNDO/S-CI method. Based on the results of a configuration anal., a simple mols.-in-mol.-type model is proposed which in a semiquant. manner completely accounts for the characteristic dependence of the UV spectra of these compounds on the position of the substituent.

Zeitschrift fuer Naturforschung, Teil A: Physik, Physikalische Chemie, Kosmophysik published new progress about Quantum chemistry. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Application In Synthesis of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Anjie published the artcileMetal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols, Recommanded Product: 6-Methoxybenzofuran, the main research area is metal free oxidative carbon bond cleavage heteroaryl alc.

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Organic Letters published new progress about C-C bond cleavage. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ueno, Atsushi published the artcileCopper-Catalyzed Formal C-H Carboxylation of Aromatic Compounds with Carbon Dioxide through Arylaluminum Intermediates, Safety of 6-Methoxybenzofuran, the main research area is aryl carboxylic acid regioselective preparation; aromatic compound alkyl amido lithium aluminate deprotonative alumination; carbon dioxide arylaluminum carboxylation copper catalyst; aromatic compounds; carbene ligands; carbon dioxide; carboxylation; copper.

The C-H bond carboxylation of various aromatic compounds with CO2 was achieved by the deprotonative alumination with a mixed alkyl amido lithium aluminate compound iBu3Al(TMP)Li followed by the NHC-copper-catalyzed carboxylation of the resulting arylaluminum species, which afforded the corresponding carboxylation products in high yield and high selectivity. In addition to benzene derivatives, heteroarenes such as benzofuran, benzothiophene, and indole derivatives are also suitable substrates. Functional groups such as Cl, Br, I, vinyl, amide, and CN could survive the reaction conditions. Some key reaction intermediates such as the copper aryl and iso-Bu complexes and their carboxylation products were isolated and structurally characterized by X-ray crystallog. analyses, thus offering important information on the reaction mechanism.

Chemistry – An Asian Journal published new progress about Alumination (deprotonative, regioselective). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Safety of 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Jun published the artcilePalladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N’-Acyl Arylhydrazines, Recommanded Product: 6-Methoxybenzofuran, the main research area is benzofuran acyl arylhydrazine palladium catalyst TEMPO regioselective arylation; arylbenzofuran preparation.

A novel ligand-free palladium-catalyzed C-2 arylation of benzofurans has been developed using N’-acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional-group tolerance and highly regioselective products with good to excellent yields.

European Journal of Organic Chemistry published new progress about Arylation catalysts (regioselective). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Okuyama, Tadashi published the artcileSubstituent effects in the benzofuran system. I. Proton and carbon-13 chemical shifts, Name: 6-Methoxybenzofuran, the main research area is NMR benzofuran substituent effect.

PMR and 13C NMR spectra of benzofuran and its derivatives (2-Me, 3-Me, 5-Me, 6-Me, 5-MeO, 6-MeO, 5-Cl) have been measured. The chem. shifts of 2-H and 2-C of 5- and 6-substituted derivatives obeyed a modified Hammett equation, δ = ρ1σ1 + ρ2σ2 +δ0. Electronic effects were transmitted mainly through the bond 8-3. The ground state electronic structure was similar to that of styrene rather than phenyl vinyl ether.

Bulletin of the Chemical Society of Japan published new progress about Linear free energy relationship. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Name: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Paymode, Dinesh J. published the artcileStudies toward the Total Synthesis of Parvifolals A/B: An Intramolecular o-Quinone Methide [4 + 2]-Cycloaddition To Construct the Central Tetracyclic Core, Category: benzofurans, the main research area is parvifolol tetracyclic core preparation cycloaddition.

Two different approaches comprising the intramol. [4+2]-cycloaddition of in situ generated o-quinone methides (o-QMs) have been explored to construct the central tetracyclic core of parvifolols A/B. At the outset, a cross-pinacol coupling of 2-formyl-tri-O-Methylresveratrol with 4-methoxysalicylaldehyde followed by acid treatment were found to provide the desired tetracyclic core (I) with an internal olefin. The requisite pendant aryl group has been introduced by a Pd-catalyzed direct coupling of corresponding diazonium salt.

ACS Omega published new progress about [4+2] Cycloaddition reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem