Song, Shu-Yong published the artcileAn improved and scale-up synthesis of 6-hydroxybenzofuran, Synthetic Route of 50551-63-8, the main research area is hydroxybenzofuran green synthesis scale up.
An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.
Research on Chemical Intermediates published new progress about Green chemistry. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Synthetic Route of 50551-63-8.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem