Ueno, Atsushi published the artcileCopper-Catalyzed Formal C-H Carboxylation of Aromatic Compounds with Carbon Dioxide through Arylaluminum Intermediates, Safety of 6-Methoxybenzofuran, the main research area is aryl carboxylic acid regioselective preparation; aromatic compound alkyl amido lithium aluminate deprotonative alumination; carbon dioxide arylaluminum carboxylation copper catalyst; aromatic compounds; carbene ligands; carbon dioxide; carboxylation; copper.
The C-H bond carboxylation of various aromatic compounds with CO2 was achieved by the deprotonative alumination with a mixed alkyl amido lithium aluminate compound iBu3Al(TMP)Li followed by the NHC-copper-catalyzed carboxylation of the resulting arylaluminum species, which afforded the corresponding carboxylation products in high yield and high selectivity. In addition to benzene derivatives, heteroarenes such as benzofuran, benzothiophene, and indole derivatives are also suitable substrates. Functional groups such as Cl, Br, I, vinyl, amide, and CN could survive the reaction conditions. Some key reaction intermediates such as the copper aryl and iso-Bu complexes and their carboxylation products were isolated and structurally characterized by X-ray crystallog. analyses, thus offering important information on the reaction mechanism.
Chemistry – An Asian Journal published new progress about Alumination (deprotonative, regioselective). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Safety of 6-Methoxybenzofuran.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem