Martin-Santamaria, Sonsoles published the artcileNew scaffolds for the design of selective estrogen receptor modulators, Recommanded Product: 6-Methoxybenzofuran, the main research area is estrogen receptor modulator antitumor pancreatic cancer.
In the present work we report the synthesis of four new ER ligands which can be used as scaffolds for the introduction of the basic side chains necessary for antiestrogenic activity. Affinities and agonist/antagonist characterization of the ligands for both ERα and ERβ have been determined in a competitive radioligand assay, and in an in vitro coactivator recruitment functional assay, resp. Mol. modeling techniques have been used in order to rationalize the exptl. results. Compound 2 is reported as a novel ERβ-agonist/ERα-antagonist. Two compounds show an interesting antitumor profile towards two pancreatic cancer cell lines and have been selected for in vivo assays.
Organic & Biomolecular Chemistry published new progress about Antitumor agents. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem