Category: 6940-49-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

Next, 0.75 g (2.0 mmol) of the compound of the structural formula (3), 0.64 g (3.0 mmol) of 3-bromophthalide and 10 ml of acetonitrile were placed in a 100 ml recovery flask, and the mixture was stirred at 70 C. for 6 hours under a nitrogen stream went. After completion of the reaction, the precipitated crystals were filtered and washed with acetonitrile to obtain 0.83 g (yield: 70%) of halide (I, Br mixed) of exemplified compound A-4. Next, an aqueous solution of 0.41 g (2.5 mmol) of ammonium hexafluorophosphate was added dropwise to an aqueous solution of 0.5 g (0.84 mmol) of the halogen compound of exemplified compound A-4 and stirred for 2 hours. After completion of the reaction, the precipitated white crystals were filtered, washed with water and dried at room temperature under reduced pressure to obtain 0.40 g (yield 70%) of exemplified compound A-4., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; CANON INCORPORATED; TAMURA, TETSUYA; IGAWA, SATOSHI; YAMADA, KENJI; (27 pag.)JP2017/197477; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

EXAMPLE 10 To a stirred solution of 10.65 g of 3-bromophthalide in 120 ml of dimethylformamide at room temperature is added 15.9 g of sodium 2-(2,6-dichloroanilino)-phenylacetate. The reaction mixture is stirred 24 hours at the room temperature, and then poured into 500 ml of ice water. After extraction with chloroform, the aqueous phase is washed with an aqueous solution of sodium bicarbonate, then with water and finally it is dried on anhydrous sodium sulfate and evaporated to dryness to yield the phthalidyl 2-(2,6-dichloroanilino)-phenylacetate; yield 70%., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Patent; Resfar S.r.I.; US4529737; (1985); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) Preparation of N,N,N-triethyl-3-oxo-1,3-dihydro-1-isobenzofuranylammonium bromide STR11 A mixture of 8.52 g (40 mmol) of 3-bromo-1,3-dihydro-1-isobenzofuranone 1 and 27.87 ml (200 mmol) of triethylamine in 85 ml of tetrahydrofuran is allowed to react at room temperature for 96 hours, and the precipitating crystals are filtered and washed with dichloromethane to give 11.04 g of the titled compound 2. (Yield: 88%) m.p. 173-174 C. NMR: deltad6 DMSO 1.25 (t, J=8.0 Hz, 9H), 3.58 (q, J=8.0 Hz, 6H), 7.16 (s, 1H), 7.80-8.23 (m, 4H). Elemental analysis (%) Calcd: C, 53.51; H, 6.42; N, 4.46 (for C14 H20 NO2 Br). Found: C, 53.07; H, 6.42; N, 4.52.

6940-49-4, The synthetic route of 6940-49-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shionogi & Co., Ltd.; US4605738; (1986); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem