Chen, Shang-Ke published the artcileMoracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor, Application In Synthesis of 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(9), 3261-3264, database is CAplus and MEDLINE.
Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug ‘Sang-Bai-Pi’ (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC50 values of 2.9, 4.5, >40, and >100 μM, resp. Our mol. docking and 8 ns mol. dynamics (MD) simulations demonstrated that moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics anal. of its analog moracin C was carried out to qual. validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.
Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem