Day: November 22, 2022

A new coumestan glucoside from Eclipta prostrata was written by Seo, Young Ju;Kil, Hyun Woo;Rho, Taewoong;Yoon, Kee Dong. And the article was included in Natural Product Sciences in 2020.Formula: C16H10O7 The following contents are mentioned in the article:

Eclipta prostrata is an annual herb, belonging to Asteraceae family, and has been traditionally used to improve immunity and treat hepatitis and bacterial disease in Korea. In this study, a new coumestan glucoside (1) along with ten known compounds (2 – 11) was isolated from E. prostrata. The chem. structures of isolates were elucidated to be wedelolactone-9-O-β-D-glucopyranoside (1), wedelolactone (2), demethylwedelolactone (3), apigenin (4), apigenin-7-sulfate (5), luteolin (6), luteolin-7-sulfate (7), luteolin-7-O-β-D-glucopyranoside (8), pratensein-7-O-β-D-glucopyranoside (9), 3,4-di-O-caffeoylquinic acid (10) and 3,5-di-O-caffeoylquinic acid (11) based on the spectroscopic evidence. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Purification of wedelolactone from Eclipta alba and evaluation of antioxidant activity was written by Ding, Hui;Wang, Yongqiang;Gao, Yujie;Han, Xu;Liu, Shejiang;Tang, Guiwen;Li, Jiaqi;Zhao, Dan. And the article was included in Separation Science and Technology in 2017.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

A hybrid chromatog.-crystallization process to purify wedelolactone obtained from Eclipta alba was developed. The crude extract was obtained by microwave-assistant extraction and purified by silica gel column chromatog. in which dichloromethane-methanol-acetic acid solution was used as the eluent. Dilution crystallization was employed to perform the final purification To optimize the processing parameters, single factor anal. and response surface methodol. were employed. The results indicated that the purification yield and purity of wedelolactone could reach 77.66% and 99.46%, resp. Antioxidant assays showed that the products had strong antioxidant and free radical scavenging activity which was close to oligomeric proantho cyanidins. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Identification of natural dyes extracted from archaeological textiles using liquid chromatography with mass spectrometry detection was written by Kohout, D.;Videna, I.;Chudoba, J.;Brezinova, H.. And the article was included in Chemicke Listy in 2016.Category: benzofurans The following contents are mentioned in the article:

All the three types of natural dyes under investigation – direct, vat and mordant – were extracted by a solvent mixture containing methanol, dichloromethane, and formic acid in a ratio of 70:25:5. For the identification, highresoln. mass spectrometry (HR-LC-MS) was used. The best results were achieved using neg. electrospray ionization. In medieval textiles exploration from the New Town of Prague, dyestuffs from madder, woad, crimson coccids, weld, buckthorn, brazilwood, and tannins from oak galls were found. HR-LC-MS analyses confirmed the usage of various combinations of dyestuffs leading to the formation of new types of colors. The most frequent combinations were the fusion of red madder with blue woad, as well as combinations of madder with yellow weld and madder with crimson coccids. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Voltammetric study of multiwalled carbon nanotube modified screen printed carbon electrode for the determination of a phytoconstituent wedelolactone was written by Saxena, Sachin;Kumar Verma, Sudhir;Satsangee, Soami P.. And the article was included in Materials Today: Proceedings in 2018.Electric Literature of C16H10O7 The following contents are mentioned in the article:

Multiwalled carbon nanotube based screen printed sensor was fabricated and utilized for the cyclic voltammetric (CV) study of a phytoconstituent wedelolactone (WDL). The analyte system was studied with Britton Robinson buffer as the supporting electrolyte. Square wave voltammetry (SWV) technique was performed for the optimization of the pH, where the pH (2.5) of the system was optimized for further investigation of the analyte system. Multiwalled carbon nanotube modified screen printed electrode (M-SPE) offered high sensitivity towards WDL as compared to the bare screen printed electrode (SPE). Voltammetric studies with M-SPE revealed the oxidation of WDL with two oxidation peaks (a1 and a2) with Ea1 = 0.08V and Ea2 =0.5 V with scan rate varying from 10-120 mV/s and exhibits diffusion-controlled process. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Electric Literature of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Electric Literature of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Distinctive pharmacological activities of Eeclipta alba and it’s coumestan wedelolactone was written by Balakrishnan, Purushothaman;Sekar, Gowtham Kumar;Ramalingam, Prasanna Srinivasan;Nagarasan, Suganthi;Murugesan, Vasumathi;Shanmugam, Kumaran. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2018.SDS of cas: 524-12-9 The following contents are mentioned in the article:

A review. Eclipta alba Linn. (Eclipta prostrata) is a perennial herb belongs to the family Asteraceae which is widespread all over the world especially in south Asian countries like India, Nepal, China and Thailand. Because of its numerous pharmacol. activities, it is used in Siddha, Unani and Ayurveda to treat skin infections, headache, toothache and other such ailments. It possess anti-inflammatory, anti-fibrotic, anti-osteoporotic, anti-cancer and hepatoprotective activities due to the phytochems. like di-Me wedelolactone and wedelolactone present in it. The coumestan wedelolactone has potent activity against human pathogens like Bacillus subtilis, Pseudomonas aeruginosa, E.coli and Salmonella typhi. We pen down this review to investigate the predominant pharmacol. activities of coumestan wedelolactone. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9SDS of cas: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A comprehensive quality evaluation method based on C30-HPLC and an analytic hierarchy process for the Chinese herbal formula, Erzhiwan was written by Nie, Ying;Yao, Weifeng. And the article was included in Molecules in 2018.Related Products of 524-12-9 The following contents are mentioned in the article:

The quant. anal. of multiple indexes remains an important quality evaluation method of traditional Chinese medicine (TCM) herbal formulas. The Chinese Pharmacopoeia 2015 only stipulates the content of a single component, specnuezhenide, in Erzhiwan composed of the Fructus Ligustri Lucidi (FLL) powder and aqueous extracts of Herba Ecliptae (HE). To generalize the intrinsic quality of Erzhiwan, a novel C30-HPLC method with good precision, accuracy, and reproducibility was developed for the simultaneous determination of six compounds, including two isomers, and then an analytic hierarchy process was further applied to integrate and discriminate the quality of four samples prepared via different methods. The results of the anal. were in agreement with the antioxidant tests in vitro. This comprehensive strategy could provide a reference and suggestions for the improvement of the quality evaluation method of TCM herbal formulas. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer was written by Yu, Dou;Yu, Qin;Lei, Jun-qiang;Guo, Shun-lin. And the article was included in Biomedicine & Pharmacotherapy in 2018.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Platinum-based chemotherapeutic drugs, especial cisplatin, are the most common and effective anticancer drugs to treat the non-small cell lung cancer (NSCLC), but the major obstacle of this treatment is the resistance to chemotherapeutic drugs due to the anti-apoptosis of cancer cells. In our study, we found that Canopy homolog 2 (CNPY2) is increased in NSCLC tissues compared to the normal lung tissues, and the upregulation of CNPY2 is correlated with poor survival. Next, colony formation, annexin V-binding and TUNEL assays revealed that overexpression of CNPY2 inhibits the apoptosis of NSCLC cells induced by cisplatin. Further assays demonstrated that the anti-apoptosis may be aroused by the hyperactivation of NF-κB signaling pathway, and blocking the NF-κB pathway promotes the apoptosis of CNPY2-upregulating cells. The above results suggest that CNPY2 can serves as a therapeutic target to promote the effect of chemotherapy in NSCLC. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Validated UPLC-MS/MS method for quantification of seven compounds in rat plasma and tissues: Application to pharmacokinetic and tissue distribution studies in rats after oral administration of extract of Eclipta prostrata L. was written by Du, Guangyan;Fu, Lingling;Jia, Jun;Pang, Xu;Yu, Haiyang;Zhang, Youcai;Fan, Guanwei;Gao, Xiumei;Han, Lifeng. And the article was included in Biomedical Chromatography in 2018.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

A rapid, sensitive and specific ultra-high-performance liquid chromatog. coupled with tandem mass spectrometry (UPLC-MS/MS) method was developed to investigate the pharmacokinetics and tissue distribution of Eclipta prostrata extract Rats were orally administrated the 70% ethanol extract of E. prostrata, and their plasma as well as various organs were collected. The concentrations of seven main compounds, ecliptasaponin IV, ecliptasaponin A, apigenin, 3′-hydroxybiochanin A, luteolin, luteolin-7-O-glucoside and wedelolactone, were quantified by UPLC-MS/MS through multiple reactions monitoring method. The precisions (RSD) of the analytes were all <15.00%. The extraction recoveries ranged from 74.65 to 107.45% with RSD â‰?15.36%. The matrix effects ranged from 78.00 to 118.06% with RSD â‰?15.04%. To conclude, the present pharmacokinetic and tissue distribution studies provided useful information for the clin. usage of Eclipta prostrata L. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Analysis of chemical components in herbal formula Qi Bai Granule by UPLC-ESI-Q-TOF-MS was written by Zhang, Chengmeng;He, Yi;Li, Tingting;Miao, Xinglong;Song, Meiting;Qian, Changmin;Li, Ruiming. And the article was included in Natural Product Research in 2019.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Qi Bai Granule (QBG), a traditional Chinese medicine formula for the treatment of idiopathic thrombocytopenic purpura, is composed of seven herbs. It is necessary to learn its chem. composition for quality control. In this study, a method for rapid separation and structural identification of the constituents in QBG was established by UPLC-ESI-Q-TOF-MS in neg. and pos. ion mode. As a result, 112 compounds, such as triterpenoids, flavonoids and monoterpenes were detected. Based on the retention times, accurate masses, fragment ions, related literatures, and/or authentic standards, 107 compounds were unambiguously identified or tentatively characterized. Addnl., 20% monarch, 50% minister, 5% assistant and 24% guide drugs of 112 compounds were detected, which on the whole was consistent with the compatibility of QBG. The results would provide a scientific basis for the quality control, quant. anal. and further study in vivo or vitro of QBG. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway was written by Zhu, Mao-mao;Wang, Long;Yang, Dang;Li, Chao;Pang, Shi-ting;Li, Xing-hua;Li, Ru;Yang, Bing;Lian, Yuan-pei;Ma, Liang;Lv, Qing-lin;Jia, Xiao-bin;Feng, Liang. And the article was included in Biomedicine & Pharmacotherapy in 2019.HPLC of Formula: 524-12-9 The following contents are mentioned in the article:

The acute kidney injury(AKI) caused by nephrotoxic drugs contributes to inflammation and oxidative injury in podocytes. Wedelolactone (WED), a natural compound, is found with activities as anti-inflammation, anti-oxidative, anti-free radical,and etc. In this present study, MPC-5 cells were exposed to the nephrotoxic drugs doxorubicin (DOX). The results showed that WED significantly increased the SOD activity, CAT and GSH-Px levels, while significantly decreased the MDA content and ROS levels in DOX-induced MPC-5 cells. WED could also significantly decrease the levels of cytokines IL-6, MCP-1, TNF-α, and TGF-β1. Addnl., the activation and phosphorylation of IκKα, IκBα and NF-κB p65 was inhibited by WED. The co-treatment of PDTC (NF-κB inhibitor) and WED significantly reduced NF-κB p65 phosphorylation. These findings suggested that WED alleviated inflammation and oxidative stress of doxorubicin-induced MPC-5 cells through IκK/IκB/NF-κB signaling pathway. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9HPLC of Formula: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.HPLC of Formula: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem