Pd-Catalyzed Synthesis of Aryl and Heteroaryl Triflones from Reactions of Sodium Triflinate with Aryl (Heteroaryl) Triflates was written by Smyth, Lynette A.;Phillips, Eric M.;Chan, Vincent S.;Napolitano, Jose G.;Henry, Rodger;Shekhar, Shashank. And the article was included in Journal of Organic Chemistry in 2016.Application In Synthesis of Benzofuran-5-ol This article mentions the following:
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroaromatic compounds were tolerated under the neutral reaction conditions. The order of reactivity ArOTf ≥ ArCl ≥ ArBr is consistent with transmetalation being a slow step of the reaction. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Application In Synthesis of Benzofuran-5-ol).
Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of Benzofuran-5-ol
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem