A convenient synthetic route to 7,8-fused heterocyclic ring derivatives of (S)-2,3-dihydro-1,4-benzodioxin-2-methanol was written by Andrew, Michael;Birch, Alan M.;Bradley, Paul A.. And the article was included in Synthesis in 1999.Synthetic Route of C8H6O2 This article mentions the following:
A much improved synthesis of (S)-2,3-dihydro-7H-1,4-dioxino[2,3-e]indole-2-methanol is described, which is shorter, higher-yielding, and less hazardous than the previous synthesis of its racemic form. This novel procedure allows preparation of multigram quantities of the enantiomerically pure compound Application of this methodol. to different 5-hydroxy heterocycles enables access to furo[3,2-f][1,4]benzodioxins, thieno[3,2-f][1,4]benzodioxins, and 1,4-dioxino[2,3-e]indazoles. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Synthetic Route of C8H6O2).
Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C8H6O2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem