Effects of solvent on the direction of the Nenitzescu reaction was written by Mukhanova, T. I.;Alekseyeva, L. M.;Kuleshova, Ye. F.;Sheinker, Yu. N.;Granik, V. G.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1993.Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone This article mentions the following:
Nenitzescu heterocyclization reaction of enamino ketones RNHCMe:CHAc (R = H, Me, Ph, 4-MeOC6H4) with p-benzoquinone in AcOH afforded benzofuran I in up to 62% yield, whereas indoles II were obtained in MeNO2 (up to 53% yield). Similar results obtained for RNHCMe:CHBz (R = e.g., H, Me, Ph, benzyl). The mechanism was discussed. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone).
1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem