With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
General procedure: To substituted phthalic anhydride (1.0 eq.) in 0.5 mL of DMSOwas added 4-aminoquinoline based diamines (1.0 eq.) in a microwavereaction vial. The vessel was sealed with a PTFE cap andheated to 160 ¡ãC for 2 min in a microwave reactor. After completionof the reaction as evident from TLC, the vessel contents werepoured in water (20 mL) and extracted with ethyl acetate(2 30 mL). The organic layers were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure toyield the crude product which was re-crystallized using absoluteethanol.
The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Rani, Anu; Singh, Amandeep; Gut, Jiri; Rosenthal, Philip J.; Kumar, Vipan; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 150 – 156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem