With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
652-39-1, Combine the two ammonium salt mixtures from Example 1 (8.86 g, 1 eq), NaBH4 (8.37 g, 5 eq), and tetrahydrofuran (123 ml) into the reaction flask and allow the mixture to cool.A solution of BF3 in tetrahydrofuran (30.77 g, 5 eq) was added dropwise and incubated.After the addition was complete, the mixture was stirred and refluxed overnight. Methanol (30 ml) was added, 100 ml of water was added, and the pH was adjusted by adding hydrochloric acid and heating to 60¡ãC. After cooling, add water 300ml, extract with methyl tert-butyl ether, take the aqueous layer, adjust the pH with NaOH, extract with n-butanol, wash with water,It was evaporated to dryness to afford 6.30 g of a mixture of the compound of formula I-1 and the compound of formula I-2 in a yield of 92percent.
652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.; Shen Qirong; Yuan Xiangxiang; Gao Hongjun; Li Yuanqiang; (10 pag.)CN107915672; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem