Simple exploration of 59434-19-4

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

59434-19-4, 4-Aminophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-((dimethylamino)methyl)benzaldehyde (539 mg, 3.3 mmol) and 4-aminoisobenzofuran-1(3H)-one (223 mg, 1.5 mmol) in ethyl propionate (14 mL) was cooled to 0 C. A solution of sodium methoxide in methanol [sodium (138 mg, 6 mmol) in methanol (4 mL)] was then added dropwise. After the addition, the mixture was stirred at room temperature for 20 hr. The mixture was quenched with water (10 mL) and solvent was removed in vacuum. The residue was dissolved in water, and then extracted with ethyl acetate (50 mL¡Á3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give crude product. The crude product was purified by chromatography (silica gel, petroleum ether/ethyl acetate=100:1 to 10:1) to give a mixture of methyl 2,3-bis(4-((dimethylamino)methyl)phenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and ethyl 2,3-bis(4-((dimethylamino)methyl)phenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate (165 mg) as a light yellow solid

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 13414-56-7

As the paragraph descriping shows that 13414-56-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13414-56-7,2,3-Dihydrobenzofuran-7-amine,as a common compound, the synthetic route is as follows.

7-Aminobenzo-2,3-dihydrofuran (3 g, 22.22 mmol) was dissolved in N, N-dimethylformamide (7 mL) and thereaction solution was cooled to 0C. A solution of N-bromosuccinimide (3.93 g, 22.22 mmol) in N,N-dimethylformamide(7 mL) was then added dropwise to the above solution over 30 minutes. After the addition, stirring was continued for 30minutes. The reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (100 mL). The organicphase was washed with saturated sodium chloride solution (50 mL 3 2), dried over anhydrous sodium sulfate, filtered,and the filtrate was concentrated under reduced pressure. And the residue was purified by silica gel column chromatography(petroleum ether: ethyl acetate = 10: 1) to deliver a yellow solid15-d (2.5 g, yield: 53%).LC-MS (ESI): m/z =214 (M+H)+

As the paragraph descriping shows that 13414-56-7 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; ZHANG, Nong; XU, Zusheng; WANG, Tinghan; WANG, Yuguang; (99 pag.)EP3287463; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 54008-77-4

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 90843-31-5

As the paragraph descriping shows that 90843-31-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

Preparation of -(2,3-dihydrobenzofuran-5-yl)acetamide Into a 2000 mL round-bottom flask, was placed a solution of 1-(2,3-dihydrobenzofuran-5-yl)ethanone (67 g, 413.58 mmol, 1.00 equiv) in MeOH (600 mL). To this was added NH2OH.HCl (34.5 g, 496.40 mmol, 1.20 equiv). To the mixture was added pyridine (Py, 42.5 g, 537.97 mmol, 1.30 equiv). The resulting solution was allowed to react, with stirring, overnight while the temperature was maintained at room temperature. The mixture was concentrated by evaporation under vacuum using a rotary evaporator. The residue was dissolved in 100 mL of water. The resulting solution was extracted two times with 100 mL of EtOAc and the organic layers combined and dried over Na2SO4 and concentrated by evaporation under vacuum using a rotary evaporator. This resulted in 70 g (crude) of 1-(2,3-dihydrobenzofuran-5-yl)ethanone oxime. HCl gas was bubbled through a solution of the oxime (70 g) in Ac2O (86 mL) and HOAc (500 mL). The resulting solution was allowed to react, with stirring, overnight at 20 C. The precipitate was poured into ice/water. The mixture was stirred for 4 h. A filtration was performed. The solid was product (part 1). The filtrate was extracted two times with dichloromethane and was dried over Na2SO4 and concentrated. The solid was also product (part 2). Two parts combined and this resulted in 70 g (86%) N-(2,3-dihydrobenzofuran-5-yl)acetamide as a brown oil.

As the paragraph descriping shows that 90843-31-5 is playing an increasingly important role.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; US2008/318941; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 57319-65-0

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Nitrophthalide (10 mmol) was dissolved in ethyl acetate (100 mL) and methanol (25 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.2 g). After 24 h the reaction mixture was filtered through a bed of celite and the filtrate was removed under reduced pressure.The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide. 6-Hydroxyphthalide was synthesized by reacting a cold suspension of 6-aminophthalide (3 mmol) in 10 mL H2SO4 (50%) with a cold solution of NaNO2 (3.5 mmol in 3 mL H2O) to yield the diazonium salt. The resulting solution was added to boiling (125 C) H2SO4 (50%, 20 mL) and the reaction mixture was boiled for 5 min. The reaction was rapidly cooled in an ice bath, and subsequently extracted to diethyl ether (3×20 mL). The ether portions were combined, washed with a saturated solution of NaHCO3 (25 mL) and dried over anhydrous Na2SO4. The ether was removed under reduced pressure, leaving the brown 6-hydroxyphthalide residue. Yield 65%; m.p. 198-200 C; 1H NMR (300MHz, DMSO) delta 5.25 (s, 2H), 7.15-7.18 (m, 2H), 7.39 (d, J=9.0 Hz, 1H); ESI-MS m/z: 150.9 [M+H]+.

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

Reference£º
Article; Wang, Zhimin; Wu, Jiajia; Yang, Xuelian; Cai, Pei; Liu, Qiaohong; Wang, Kelvin D.G.; Kong, Lingyi; Wang, Xiaobing; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5929 – 5940;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 10242-08-7

As the paragraph descriping shows that 10242-08-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-08-7,5-Methoxybenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl (l -aminopiperidin-4-yl)carbamate (224 mg, 1 04 mmol, 1.0 equiv) in DMF (5 mL) was added HATU (790 mg, 2 08 mmol, 2.0 equiv) at RT and stirred for 10 minutes. Then 5-methoxybenzofuran-2 -carboxylic acid (200 mg, 1.04 mmol, 1.0 equiv) was added followed by the addition of DIPEA (0.6 ml,, 3.12 mmol, 3 0 equiv). The resulting reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL c 2). The combined organic layer was washed with water (30mL), brine solution (30 mL x 2), dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain tert-butyl (l-(5-methoxybenzofuran-2-carboxamido)piperidin-4-yl)carbamate (300 mg, 74 % Yield) as an off white solid. LCMS 390.2 | M 1 1 | ; N .MR (400 MHz, DMSQ-tie) 6 9.62 (s, 1 H), 7.53 (d, .7=8 77 Hz, 1 H), 7.44 (s, 1 H), 7.24 (br s, 1 H), 6.97 – 7.08 (m, 1 H), 6 84 (d, .7=6 58 Hz, 1 H), 3.79 (s, 3 H), 3.23 (br s , 1 H), 2.95 (d, .7=10 09 Hz, 2 H), 2.62 – 2 81 (m, 2 H), 1.74 (d, 7=9.65 Hz, 2 H), 1.53 (d, ./ 10.52 Hz, 2 H), 1.38 (s, 9 H).

As the paragraph descriping shows that 10242-08-7 is playing an increasingly important role.

Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 54008-77-4

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol. 4.2.1. 2,3-Dimethyl-1H-benzofuro[2,3-b]pyrrole (4a)Yield 81% (376 mg); White solid; mp: 220e222C; IR (ATR,cm1): 3376 (NH);1H NMR (CDCl3, 400 MHz) d: 2.07 (s, 3H, CH3),2.30 (s, 3H, CH3), 5.00 (s, 1H, NH), 7.38 (t, 1H, J 7.6 Hz, Ar-H), 7.52(t, 1H, J 6.8 Hz, Ar-H), 7.69 (d, 1H, J 9.6 Hz, Ar-H), 7.90 (d, 1H, J 10 Hz, Ar-H) ppm;13C NMR (CDCl3, 100 MHz) d: 8.2, 11.7, 103.3,106.9, 112.1, 120.8, 123.2, 124.4, 127.3 (2C), 145.9, 157.2 ppm; LCMSm/z: [MH]Calcd for C12H12NO 186.08; Found 186.10; Anal. Calcdfor C12H11NO: C, 77.81; H, 5.99; N, 7.56. Found: C, 77.75; H, 5.90; N,7.51.

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 61090-37-7

As the paragraph descriping shows that 61090-37-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61090-37-7,2,3-Dihydrobenzofuran-4-amine,as a common compound, the synthetic route is as follows.

Place 4-amino-2,3-dihydrobenzofuran (405 mg, 3.0 mmol) in a round bottom flask,Concentrated sulfuric acid (450 muL, 8.3 mmol.) And 6.0 mL of deionized water were added to dissolve, and the reaction system was cooled in an ice-salt bath. A deionized aqueous solution of sodium nitrite (242.2 mg of sodium nitrite in 1.5 mL of deionized water, 3.5 mmol.) Was added dropwise to the system. The solution turned red. The reaction was stirred at 0 C for 30 minutes. After adding 3.0 mL of ether, a deionized aqueous solution of potassium iodide (2.0 g of potassium iodide in 1.5 mL of deionized water, 12 mmol.) Was added dropwise, and stirred for 3 hours. After the reaction was completed, a saturated sodium thiosulfate solution was added and extracted three times with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to obtain a crude product.The crude product was subjected to petroleum ether column chromatography to obtain 518 mg of a relatively pure white 4-iodo-2,3-dihydrobenzofuran solid product in a yield of 70%.

As the paragraph descriping shows that 61090-37-7 is playing an increasingly important role.

Reference£º
Patent; Wuhan University; Zhou Qianghui; Gao Shijun; Qian Guangyin; (10 pag.)CN110483456; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 62119-70-4

As the paragraph descriping shows that 62119-70-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62119-70-4,2-Benzofuranacetic acid,as a common compound, the synthetic route is as follows.

Example 49 Synthesis of N-[(benzofuran-2-yl)acetyl]alanine iso-butyl ester Following General Procedure I above, and using benzofuran-2-ylacetic acid (Maybridge) and alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure. NMR data was as follows: 1H-nmr (CDCl3): delta = 7.51 (m, 1H), 7.44 (m, 1H), 7.25 (m, 2H), 6.67 (s, 1H), 4.60 (m, 1H), 3.87 (m, 2H), 3.77 (s, 2H), 1.88 (m, 1H), 1.38 (d, 3H), 0.87 (d, 6H). C17H21NO4 (MW = 303, Mass Spectroscopy (MH+ 304)). GENERAL PROCEDURE IP-EPC coupling P-EPC coupling employs an amino acid ester and a substituted acetic acid compound. The acetic acid derivative is well known in the art and is typically commercially available. The amino acid ester is prepared by conventional methods from the known and typically commercially available N-BOC amino acid as described in GENERAL PROCEDURE J below. Specifically, the appropriate amino ester free base (0.0346 mmols) and substituted phenylacetic acid (0.069 mmols) were dissolved in 2.0 mL CHCl3 (EtOH free), treated with 150 mg of P-EPC (0.87 meq./g) and the reaction was mixed for 4 days at 23C. The reaction was filtered through a plug of cotton, rinsed with 2.0 mL of CHCl3 and the filtrate evaporated under a stream of nitrogen. The purity of each sample was determined by 1H NMR and ranged from 50% to >95%. Between 8.0 and 15.0 mg of final product was obtained from each reaction and was tested without additional purification

As the paragraph descriping shows that 62119-70-4 is playing an increasingly important role.

Reference£º
Patent; Elan Pharmaceuticals, Inc.; ELI LILLY AND COMPANY; EP951464; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 10242-08-7

10242-08-7 5-Methoxybenzofuran-2-carboxylic acid 288638, abenzofuran compound, is more and more widely used in various.

10242-08-7, 5-Methoxybenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 7 2-(5-methoxybenzofuran-2-yl)imidazole hydrochloride R1 =H R2 =5-methoxy This was prepared from 5-methoxybenzofuran-2-carboxylic acid according to the methods a-e as described in example 1; m.p.=232-235 C. 1 H-NMR (DMSO-d6): 3.80 (s,3H), 7.10 (dd,1H), 7.40 (d,1H), 7.65 (d,1H), 7.80 (s,2H), 8.10 (s,1H). 13 C-NMR (DMSO-d6): 56.0, 104.7, 110.3, 112.7, 116.9, 121.2, 128.3, 135.6, 141.8, 150.0, 157.0.

10242-08-7 5-Methoxybenzofuran-2-carboxylic acid 288638, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S); US5310930; (1994); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem