With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol. 4.2.1. 2,3-Dimethyl-1H-benzofuro[2,3-b]pyrrole (4a)Yield 81% (376 mg); White solid; mp: 220e222C; IR (ATR,cm1): 3376 (NH);1H NMR (CDCl3, 400 MHz) d: 2.07 (s, 3H, CH3),2.30 (s, 3H, CH3), 5.00 (s, 1H, NH), 7.38 (t, 1H, J 7.6 Hz, Ar-H), 7.52(t, 1H, J 6.8 Hz, Ar-H), 7.69 (d, 1H, J 9.6 Hz, Ar-H), 7.90 (d, 1H, J 10 Hz, Ar-H) ppm;13C NMR (CDCl3, 100 MHz) d: 8.2, 11.7, 103.3,106.9, 112.1, 120.8, 123.2, 124.4, 127.3 (2C), 145.9, 157.2 ppm; LCMSm/z: [MH]Calcd for C12H12NO 186.08; Found 186.10; Anal. Calcdfor C12H11NO: C, 77.81; H, 5.99; N, 7.56. Found: C, 77.75; H, 5.90; N,7.51.
54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.
Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem