New learning discoveries about 54008-77-4

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

54008-77-4, To a solution of tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1.0 g, 3.3 mmol), 2-bromobenzofuran (0.64 g, 3.3 mmol) and tetrakis(triphenylphosphine) palladium(0) (0.5 g, 0.4 mmol) in a mixed solution of 1,4-dioxane (20 mL) and water (2.0 mL) was added sodium carbonate (1.0 g, 7.2 mmol). The reaction mixture was stirred at 90 C. under nitrogen for 12 hours. After the reaction, it was allowed to cool to room temperature, and concentrated in vacuo, then diluted with ethyl acetate (100 mL), washed with water (100 mL). The organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20) to give the pure product tert-butyl 4-(benzofuran-2-yl)benzoate as a white solid (0.65 g, 67%). 1H NMR (300 MHz, CDCl3): delta 8.06 (d, J=8.7 Hz, 2H), 7.90 (d, J=8.4 Hz, 2H), 7.62-7.53 (m, 2H), 7.32-7.25 (m, 2H), 7.14 (s, 1H), 1.62 (s, 9H).

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Constellation Pharmaceuticals, Inc.; Albrecht, Brian K.; Audia, James Edmund; Cook, Andrew S.; Gagnon, Alexandre; Harmange, Jean-Christophe; Nasveschuk, Christopher G.; US9206128; (2015); B2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 54008-77-4

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

54008-77-4, General procedure: In a hot oven-dried Schlenk tube under N2 atmosphere were added Ph3Bi (0.25 mmol, 110 mg, 1.0 equiv), 2-bromobenzofuran (0.825 mmol, 163 mg, 3.3 equiv), Cs2CO3 (0.75 mmol, 244 mg, 3.0 equiv), Pd(OAc)2 (0.025 mmol, 5.6 mg, 0.1 equiv), PPh3 (0.1 mmol, 26 mg, 0.4 equiv), and NMP (3 mL) solvent. The resulting mixture was stirred in preheated oil bath at 90 C for 1 h. After the reaction is over, the mixture was cooled, quenched with dil HCl and extracted with ethyl acetate. The combined organic extract was washed with water, brine, and dried over MgSO4 and concentrated. The crude was subjected to silica gel column chromatography (230-400 mesh) using petroleum ether as the eluent to obtain the pure 2-phenylbenzofuran (2.1) as a white solid (140 mg, 96%). The product was characterized by spectroscopy and in comparison with the literature data.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Rao, Maddali L.N.; Awasthi, Dheeraj K.; Talode, Jalindar B.; Tetrahedron Letters; vol. 53; 21; (2012); p. 2662 – 2666;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 54008-77-4

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54008-77-4, Under the protection of nitrogen, are weighing 30 g raw material C (177 mmol), 34.9 g raw material G (177 mmol), 42.6 g sodium tert-butanol (443 mmol), 0.40 g Pd (OAc)2(1.77 Mmol), 1.55 g C10104 R3 (3.54 mmol), dimethyl benzene is used for stirring and mixing, heating to 120 – 130 C, reflux reaction 5 – 7 hours, sampling TLC detection display without material remaining C; natural cooling to room temperature, water washing, over silica gel column, for refining THF, and dried to obtain the 31.6 g intermediate E, yield: 62.5%, HPLC: 99.9%. C raw material, the raw material G, […] molar ratio of 1:1: 2.5.

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yantai Jiu Mu Chemicals Co., Ltd.; Chi Shenghua; Fang Pinglei; Zhang Shicai; Cui Lisha; Cheng Daxing; Liu Kai; (27 pag.)CN109369420; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 54008-77-4

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,54008-77-4

Tert-butyl 4-(benzofuran-2-yl)benzoate. To a solution of tert-butyl 4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl) benzoate (1.0 g, 3.3 mmol), 2-bromobenzofuran (0.64 g, 3.3 mmol) and tetrakis(triphenylphosphine) palladium(O) (0.5 g, 0.4 mmol) in a mixed solution of 1 ,4-dioxane (20 mL) and water (2.0 mL) was added sodium carbonate(1.0 g, 7.2 mmol). The reaction mixture was stirred at 90C under nitrogen for 12 hours. After the reaction, it was allowed to cool to room temperature, and concentrated in vacuo, then diluted with ethyl acetate (100 mL), washed with water (100 mL). The organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, ethyl acetate/ petroleum ether = 1 :20) to give the pure product tert- butyl 4-(benzofuran-2-yl)benzoate as a white solid(0.65 g, 67%). 1H NMR (300 MHz, CDC13): delta 8.06 (d, J= 8.7 Hz, 2H), 7.90 (d, J= 8.4 Hz, 2H), 7.62-7.53 (m, 2H), 7.32-7.25 (m, 2H), 7.14 (s, 1H),1.62 (s, 9H).

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.; WO2013/75083; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 54008-77-4

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol. 4.2.1. 2,3-Dimethyl-1H-benzofuro[2,3-b]pyrrole (4a)Yield 81% (376 mg); White solid; mp: 220e222C; IR (ATR,cm1): 3376 (NH);1H NMR (CDCl3, 400 MHz) d: 2.07 (s, 3H, CH3),2.30 (s, 3H, CH3), 5.00 (s, 1H, NH), 7.38 (t, 1H, J 7.6 Hz, Ar-H), 7.52(t, 1H, J 6.8 Hz, Ar-H), 7.69 (d, 1H, J 9.6 Hz, Ar-H), 7.90 (d, 1H, J 10 Hz, Ar-H) ppm;13C NMR (CDCl3, 100 MHz) d: 8.2, 11.7, 103.3,106.9, 112.1, 120.8, 123.2, 124.4, 127.3 (2C), 145.9, 157.2 ppm; LCMSm/z: [MH]Calcd for C12H12NO 186.08; Found 186.10; Anal. Calcdfor C12H11NO: C, 77.81; H, 5.99; N, 7.56. Found: C, 77.75; H, 5.90; N,7.51.

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 54008-77-4

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem