September 14,2021 News Can You Really Do Chemisty Experiments About 54008-77-4

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Application of 54008-77-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 54008-77-4, 2-Bromobenzofuran, introducing its new discovery.

Aggrecanases are recently discovered enzymes that cleave aggrecan, a key component of cartilage. Aggrecanase inhibitors may provide a unique means to halt the progression of cartilage destruction in osteoarthritis. The synthesis and evaluation of biphenylsulfonamidocarboxylic acid inhibitors of aggrecanase-1 are reported. Compound 24 demonstrated 89% inhibition of proteoglycan degradation at 10 mug/mL and has an oral bioavailability in rat of 35%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3266O – PubChem