Tag: 57319-65-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,57319-65-0

Example 68; 2-(3-Oxo-l,3-dihydro-isobenzofuran-5-yIcarbamoyl)-pyrrolidine-l-carboxylic acid benzyl ester (Compound 6068)Using General Procedure C from 0.075 g (0.5 mmol) of 6-Amino-3H- isobenzofuran- 1 -one. MS : 381.1 (M+H4). General Procedure C; A mixture of (S)-Pyrrolidine-l,2-dicarboxylic acid 1-benzyl ester (F.W. = 249.27, 0.15 g, 0.6 mmol), HATU (F.W. = 380.25, 0.209 g, 0.55 mmol), and DIEA (0.1 mL, 0.76 mmol) in DMF (5 mL) was stirred at room temperature for 1 h.. This mixture had to be prepared each time for the reactions of the amines described in the following Examples. The individual mixtures were stirred at room temperature for 20 h., then filtered and separated by reverse phase HPLC (20-100% of buffer B; buffer A: water containing 0.1% TFA; buffer B: MeCN containing 0.1%TFA). The combined fraction was evaporated to dryness to furnish the desired products.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENELABS TECHNOLOGIES, INC.; WO2007/70556; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Nitrophthalide (10 mmol) was dissolved in ethyl acetate (100 mL) and methanol (25 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.2 g). After 24 h the reaction mixture was filtered through a bed of celite and the filtrate was removed under reduced pressure.The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide. 6-Hydroxyphthalide was synthesized by reacting a cold suspension of 6-aminophthalide (3 mmol) in 10 mL H2SO4 (50%) with a cold solution of NaNO2 (3.5 mmol in 3 mL H2O) to yield the diazonium salt. The resulting solution was added to boiling (125 C) H2SO4 (50%, 20 mL) and the reaction mixture was boiled for 5 min. The reaction was rapidly cooled in an ice bath, and subsequently extracted to diethyl ether (3×20 mL). The ether portions were combined, washed with a saturated solution of NaHCO3 (25 mL) and dried over anhydrous Na2SO4. The ether was removed under reduced pressure, leaving the brown 6-hydroxyphthalide residue. Yield 65%; m.p. 198-200 C; 1H NMR (300MHz, DMSO) delta 5.25 (s, 2H), 7.15-7.18 (m, 2H), 7.39 (d, J=9.0 Hz, 1H); ESI-MS m/z: 150.9 [M+H]+.

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

Reference£º
Article; Wang, Zhimin; Wu, Jiajia; Yang, Xuelian; Cai, Pei; Liu, Qiaohong; Wang, Kelvin D.G.; Kong, Lingyi; Wang, Xiaobing; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5929 – 5940;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem