Brief introduction of 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

To a solution of 5, 6-dichloroisobenzofuran-1, 3-dione (8.8 g, 40.6 mmol) in acetic acid (40 mL), hydrazine (1.886 ml, 48.7 mmol) was added carefully at room temperature. The mixture was stirred at 70 ¡ãC overnight under nitrogen. The reaction mixture was cooled and the solid material was collected to give the title compound, which was used without further purification (8.9 g, 90percent). LCMS (Method B): m/z 231.7 (M+H), retention time: 1.38 minutes. ?H NIVIR (DMSO-d6, 400 IVIHz) oe 11.88 (s, 2H), 8.18 (s, 2H).

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; DAI, Yujia; MICHAELIDES, Michael; (83 pag.)WO2016/123796; (2016); A1;,
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New learning discoveries about 125-20-2

As the paragraph descriping shows that 125-20-2 is playing an increasingly important role.

125-20-2, Thymolphthalein is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

preparation method as follow: thymolphthalein (4.3 g, 10 mmol), TBAHS (3. 4 g, 10 mmol), 2-acetamido-3,4,6 -tri-O-acetyl -2-deoxy- A -D-glucopyranoside (3.65g, 10 mmol) dissolved in dichloromethane and cooled down to 10 degrees. After adding 30 ml of 1N potassium carbonate aqueous solution, the mixture was stirred at room temperature for 3 hours, and the mixture was separated and dried over anhydrous sodium sulfate. The organic phase is concentrated to dry column to obtain thymolphthalein-N-acetyl-3,4,6-O-triacetyl-beta-D-glucapyranoside (Yield 4.5 g, yield 61.2%).

As the paragraph descriping shows that 125-20-2 is playing an increasingly important role.

Reference£º
Patent; Guangdong Younide Biological Technology Co., Ltd.; Sai Chi Bio-technology (Shanghai) Co., Ltd.; Su Hongwen; Lai Hua; Liang Weiye; Liu Zhiwen; (6 pag.)CN108218926; (2018); A;,
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New learning discoveries about 90843-31-5

The synthetic route of 90843-31-5 has been constantly updated, and we look forward to future research findings.

90843-31-5, 5-Acetyl-2,3-dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-[1-(3-Bromo-phenyl)-vinyl]-2,3-dihydro-benzofuran A 1.6 M solution of n-butyllithium in hexane (22.3 mL, 35.7 mmol, 1.16 eq.) was added dropwise to a solution of 1,3-dibromobenzene (8.0 g, 33.9 mmol, 1.1 eq) in 30 mL of dry tetrahydrofuran at -78 C. under nitrogen, and the mixture was stirred for 20 min. After this time, a solution of 1-(2,3-dihydro-benzofuran-5-yl)-ethanone (5.0 g, 30.8 mmol, 1.0 eq, prepared as shown in Scheme 4) in 20 mL of dry tetrahydrofuran was added over 10 minutes and the resulting solution was further stirred for 45 min. The reaction mixture was examined LCMS which showed complete conversion to the desired product. 20 mL of a saturated aqueous solution of ammonium chloride was added and the cooling bath was removed. The mixture was poured into 100 mL of a 1:1 diisopropyl ether/water mixture. The organic fraction was dried over sodium sulfate and concentrated to give a yellow oil. The oil was dissolved in 10 mL of acetic acid. 0.3 mL of 98% sulfuric acid were added and the dark solution was stirred at room temperature. After 30 min LCMS showed complete conversion to the desired product. Crushed ice was poured in the reaction mixture which was then extracted with dichloromethane. The organic fraction was collected, washed with water, sodium baicarbonate solution and dried with over sodium sulfate. The crude product was purified by flash chromatography eluding with cyclohexane. 3.5 g of clean product was obtained as colorless liquid (yield: 38%) Mass (calculated) C16H13BrO [301]; (found) [M+H+]=302 LC Rt=2.97 min (5 min method) 92%

The synthetic route of 90843-31-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang; US2009/209529; (2009); A1;,
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Brief introduction of 4265-16-1

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

Example 17 4-(Benzofuran-2-ylmethoxy)-2-(2,6-dioxo-piperidin-3-yl)-isoindole-l,3-dioneStep 1 :[211] 2-Benzofurancarbaldehyde (2.2 g, 15 mmol) was dissolved in 25 mL of methanol. To this solution was added sodium borohydride (0.28 g, 7.5 mmol) in small portions over a period of 20 minutes. Then 2 mL of water were added and the mixture was evaporated. The residue was dissolved in ethyl acetate (75 mL) and washed with water (3 x 75 mL), dried (MgSO4) and evaporated, providing 2.1 g of benzofuran-2-yl-methanol, in 95% yield; 1H NMR (CDCl3) delta 2.03 (t, J = 6.1 Hz, IH), 4.77 (d, J = 6.1 Hz, 2H), 6.66 (s, IH), 7.19-7.32 (m, 2H), 7.45-7.50 (m, IH), 7.53-7.57 (m, IH).

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

Reference£º
Patent; CELGENE CORPORATION; WO2008/115516; (2008); A2;,
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Downstream synthetic route of 13391-28-1

13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various.

13391-28-1, 5-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

j0379j 2.5 M n-butyllithium in hexanes (2.8 mE, 7.00 mmol) was added slowly to a solution of 5-methoxy-i-benzofuran(1.0 g, 6.75 mmol) in dry tetrahydrothran (15 mL) at -78 C under a nitrogen atmosphere. After 1 hour stirring at -78 C, triisopropylborate (3.12 mL, 13.5 mmol) was added drop-wise and the mixture stirred for 30 minutes at -78 C. The dry ice bath was removed, 2 M aqueous hydrochloric acid (20 mL) was added and the mixture warmed to room temperature whilst stirring overnight. The reaction mixture was poured into waler (25 mL) and extracted with diethyl ether (3 x 20 mL). The combined organics were washed with brine (20 mL), dried over magnesium sulfate, filtered and concentrated under reduced pressure. Dichloromethane (20 mL) was added and the mixture sonicated for 10 minutes. The minimum amount of methanol (ca. 1 mL) was added to ffilly dissolve the solids and the solution sonicaled for 10 minutes. Heptane (20 mL) was added and the precipitated solids collected by vacuum filtration and allowed to dry under vacuum for 2 hours to give the title compound 476 mg (37% yield) as a white solid. On NMR (500 MHz, DMSO) 8.53 (s, 2H), 7.46 (d, J= 8.94 Hz, IH), 7.39 (s, lH), 7.19 (d, J= 2.51 Hz, 1H), 6.93 (dd, J= 2.60,8.92 Hz, 1H), 3.78 (s, 3H).

13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; WITYAK, John; BARD, Jonathan; KISELYOV, Alex; BROWN, Christopher, John; GALAN, Sebastien, Rene Gabriel; PRIME, Michael, Edward; GILES, Paul, Richard; GADOULEAU, Elise, Luciennen Paulette; KRUeLLE, Thomas, Martin; CLARK-FREW, Daniel; JOHNSON, Peter, David; SCHAERTL, Sabine; HERRMANN, Frank; GRIMM, Steffen, Kaspar; KAHMANN, Jan, Dirk; SCHEICH, Christoph; COE, Samuel; HAYES, Sarah; (271 pag.)WO2016/33445; (2016); A1;,
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Brief introduction of 700-85-6

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A mixture of5-fluoro-3H-isobenzofuran-1-one (1 g, 6.6 mmol, 1 eq), N-bromosuccinimide (1.2 g,6.8 mmol, 1.03 eq) and dibenzoyl peroxide (111 mg, 0.5 mmol, 0.07 eq) in CCw is stirred at 80C for 1.5h. The precipitated is filtered and the filtrate is concentrated. The residue is partitioned between DCM andwater. The two layers are separated and the aqueous layer is extracted with DCM. The combined organiclayers are dried (filtered through phase separator) and concentrated to afford the desired product.

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; MENET, Christel, Jeanne, Marie; PALISSE, Adeline, Marie, Elise; TRICARICO, Giovanni, Alessandro; EL BKASSINY, Sandy; JAUNET, Alexis, Patrick, Claude; ALLART, Brigitte; DUTHION, Beranger; BREBION, Franck Laurent; (324 pag.)WO2019/7696; (2019); A1;,
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Analyzing the synthesis route of 13391-28-1

As the paragraph descriping shows that 13391-28-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

To 5-methoxybenzofuran (188 mg, 1.269 mmol) in THF (4.0 mL) at -78 C wasadded 1.6 N n-BuLi in hexanes (1.190 mL, 1.903 mmol) dropwise. The solution became slightly yellow. The reaction mixture was stirred at -78 C for 20 mm, followed by addition of triisopropyl borate (0.737 mL, 3.17 mmol). After 30 mm stirring at -78 C, the cooling bath was removed and the stirring was continued at room temperature for 1.5h. The reaction mixture was diluted with EtOAc, quenched with 3.0 mL of 1.0 N HC1.After stirring at room temperature for 25 mm, the organic layer was collected, washedwith brine and dried over sodium sulfate. After evaporation of solvent, the cmde product was dissolved in a small amount of chloroform/a drop of MeOH and charged to a 4 g silica gel cartridge which was eluted with hexanes for 2 mm., then a 10 mm gradient from 0% to 60%. The desired fractions were combined, concentrated and lyophilized to giveIntermediate 2A (170 mg, 0.886 mmol, 69.8 % yield) as a white solid. ?H NMR (500MHz, methanol-d4) oe 7.41 (d, J=9. 1 Hz, 1H), 7.30 (s, 1H), 7.14 (d, J2.5 Hz, 1H), 6.96 (dd, J=8.9, 2.6 Hz, 1H), 3.84 (s, 3H); LC-MS: method A, RT = 1.45 mm, MS (ESI) m/z: 149.0 (M-B(OH)2)t

As the paragraph descriping shows that 13391-28-1 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
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New learning discoveries about 15832-09-4

15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

To a solution of 6-methoxybenzofuran-3(2H)-one (58?mg, 0.354?mmol) in MeOH (5?mL) were added an aqueous solution of KOH (50%, 0.30?mL) and 3,4-dimethoxybenzaldehyde (59?mg, 0.354?mmol), and the mixture was stirred at room temperature for 2?h. The solid was then filtered, washed with cold MeOH and dried. The crude product was recrystallized from MeOH to afford 34 (25?mg, 23%) as a yellow solid. 1H NMR (CDCl3) delta 7.72 (d, 1H, J?=?8.3?Hz), 7.51 (d, 1H, J?=?1.9?Hz), 7.48 (dd, 1H, J1?=?8.3?Hz, J2?=?1.9?Hz), 6.94 (d, 1H, J?=?8.3?Hz), 6.80 (s, 1H), 6.77 (dd, 1H, J1?=?8.3?Hz, J2?=?2.1?Hz), 6.76 (s, 1H), 3.99 (s, 3H), 3.95 (s, 3H), 3.94 (s, 3H). 13C NMR (CDCl3) delta 183.0, 168.4, 167.4, 150.8, 149.2, 147.0, 126.0, 125.9, 125.6, 115.3, 113.9, 112.6, 112.2, 111.4, 96.8, 56.3, 56.2, 56.2. IR (ATR) upsilon 1596, 1516, 1442, 1424, 1292, 1283, 1261, 1169, 1145, 1122, 1091, 1043, 1015, 949, 896, 862, 835, 816, 771, 700?cm-1. HRMS (ESI) calc. for C18H17O5 [M + H]+ 313.1071, found 313.1065.

15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Olleik, Hamza; Yahiaoui, Samir; Roulier, Brayan; Courvoisier-Dezord, Elise; Perrier, Josette; Peres, Basile; Hijazi, Akram; Baydoun, Elias; Raymond, Josette; Boumendjel, Ahcene; Maresca, Marc; Haudecoeur, Romain; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 133 – 141;,
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Some tips on 496-16-2

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

Example 5; Preparation of 5-(2,3-dihydrobenzofuran-5-yl)-3-(3-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenoxy)benzyl)-5-methylimidazolidine-2,4-dione; 5-a) Preparation of 5-(2,3-dihydrobenzofuran-5-yl)-5-methylimidazolidine-2,4-dione; 2,3-Dihydrobenzofuran (10 g, 83.2 mmol) was dissolved in dichloromethane (400 mL). The resultant mixture was added sequentially with acetyl chloride (11.8 mL, 167 mmol) and aluminum chloride (33.3 g, 250 mmol) at -10 C., and stirred at -10 C. for 0.5 hour. The reaction solution was added with 5% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate and brine, dried using anhydrous sodium sulfate, and concentrated in vacuo. 1-(2,3-Dihydrobenzofuran-5-yl)ethanone (13.4 g, yield 99%) was obtained as a colorless oil.1H-NMR (CDCl3) delta: 2.55 (3H, s), 3.25 (2H, t, J=8.6 Hz), 4.67 (2H, t, J=8.6 Hz), 6.80 (1H, d, J=8.1 Hz), 7.80 (1H, dd, J=1.9, 8.1 Hz), 7.85 (1H, d, J=1.9 Hz).

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOWA COMPANY, LTD.; US2010/48610; (2010); A1;,
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Simple exploration of 69999-16-2

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

Step 3. 2~(2,3-dihydro-l~benzofuran-5-ylmethyl)-l-(3-rnethylbutyl)-N,N-bis(2,2,2-trifluoro- ethyI)-lH-benzimidazole-5-carboxamide[0168] To a mixture of 3-amino-4-[(3-methylbutyl)amino]-N,N-bis(2,2,2- trifluoroethyl)benzamide (Step 2 of the Example 1, 0.175g, 0.454 mmol, lequiv), 2,3-dihydro-l- benzofuran-5-ylacetic acid (0.089g, 0.50 mmol, 1.1 equiv) and HATU (0.19Og, 0.500 mmol, 1.1 equpsiloniv) was added a solution of DIPEA (160 muL, 0.92 mmol, 2equiv) in DMF (5 mL). The mixture was stirred overnight at room temperature. Complete consumption of the starting material was confirmed by LC-MS. DMF was removed under reduced pressure. Ethyl acetate was added to the resulting residue. The organic layer was washed once with a saturated aqueous <n=”54″/>NaHCtheta3 solution, once with brine and dried over anhydrous Na2SO4. Ethyl acetate was removed under reduce pressure. The resulting residue was dissolved in dichloroethane and a few drops of concentrated HCl were added. The mixture was stirred at 80 C for 3 hours. Complete consumption of the starting material was confirmed by LC-MS. Dichloromethane was added. The organic layer was washed once with a 2M aqueous NaOH solution, once with brine and dried over anhydrous Na2SO4. Dichloromethane was removed under reduced pressure. The resulting residue was purified by column chromatography on silica gel (hexanes/EtOAc, 50:50) to afford 2-(2,3-dmydro-l-benzofuran-5-ylmethyl)-l-(3-methylbutyl)-N,N-bis(2,2,2-trifluoro- ethyl)-lH-benzimidazole-5-carbochiamide (0.173 mg) in 72% yield. The product was dissolved in methanol (about 5 mL) and 1 equivalent of TFA was added. The mixture was stirred at room temperature for about 30 minutes. Methanol was removed under reduced pressure. Water was added and the resulting residue was lyophilized to afford 2-(2,3-dihydro-l-benzofuran-5- ymiethyl)-l-(3-me1hylbu1yl)-N,N-bis(2,2,2-trifluoro-e&yl)-lH-benzimidazole-5-carboxamide as the corresponding TFA salt. 1H NMR (400 MHz, METHANOL-D4) 6 ppm 0.96 (d, /=6.64 Hz, 6 H) 1.45 – 1.54 (m, 2 H) 1.63 – 1.75 (m, 1 H) 3.18 (t, /=8.79 Hz, 2 H) 4.32 – 4.44 (m, 6 H) 4.49 (s, 2 H) 4.54 (t, J=8.79 Hz, 2 H) 6.75 (d; /=8.20 Hz, 1 H) 7.07 (dd, J=8.20, 1.95 Hz, 1 H) 7.20 (s, 1 H) 7.58 (dd, /=8.50, 1.46 Hz, 1 H) 7.79 (d, /=0.78 Hz, 1 H) 7.87 (d, /=8.59 Hz, 1 H); MS (ESI) m/z 527.8 (MHhH)+; Anal. Calcd (%) for C26H27F6N3O2 + 1.0 TFA: C, 52.42; H, 4.40; N, 6.55. Found: C, 52.52; H, 4.27; N 6.18.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/91950; (2007); A1;,
Benzofuran – Wikipedia
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