Tag: 700-85-6

Simple exploration of 700-85-6

As the paragraph descriping shows that 700-85-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,700-85-6

250ml single-mouth bottle to join5-F-benzofuran-1 (3H) ketone 2g, absolute ethanol 120ml, dropping thionyl chloride 4.8ml, drop complete, reflux 14h, vacuum evaporated.

As the paragraph descriping shows that 700-85-6 is playing an increasingly important role.

Reference£º
Patent; Chongqing Institute of Pharmaceutical Industry Co., Ltd.; Dan, Chunyan; Cai, Pengfei; Zuo, Xiaoyong; Luo, Bin; Xie, Shouquan; Liu, Caiping; Yang, Qiaobin; (8 pag.)CN105524044; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 700-85-6

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A mixture of5-fluoro-3H-isobenzofuran-1-one (1 g, 6.6 mmol, 1 eq), N-bromosuccinimide (1.2 g,6.8 mmol, 1.03 eq) and dibenzoyl peroxide (111 mg, 0.5 mmol, 0.07 eq) in CCw is stirred at 80C for 1.5h. The precipitated is filtered and the filtrate is concentrated. The residue is partitioned between DCM andwater. The two layers are separated and the aqueous layer is extracted with DCM. The combined organiclayers are dried (filtered through phase separator) and concentrated to afford the desired product.

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; MENET, Christel, Jeanne, Marie; PALISSE, Adeline, Marie, Elise; TRICARICO, Giovanni, Alessandro; EL BKASSINY, Sandy; JAUNET, Alexis, Patrick, Claude; ALLART, Brigitte; DUTHION, Beranger; BREBION, Franck Laurent; (324 pag.)WO2019/7696; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem