With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
Example 17 4-(Benzofuran-2-ylmethoxy)-2-(2,6-dioxo-piperidin-3-yl)-isoindole-l,3-dioneStep 1 :[211] 2-Benzofurancarbaldehyde (2.2 g, 15 mmol) was dissolved in 25 mL of methanol. To this solution was added sodium borohydride (0.28 g, 7.5 mmol) in small portions over a period of 20 minutes. Then 2 mL of water were added and the mixture was evaporated. The residue was dissolved in ethyl acetate (75 mL) and washed with water (3 x 75 mL), dried (MgSO4) and evaporated, providing 2.1 g of benzofuran-2-yl-methanol, in 95% yield; 1H NMR (CDCl3) delta 2.03 (t, J = 6.1 Hz, IH), 4.77 (d, J = 6.1 Hz, 2H), 6.66 (s, IH), 7.19-7.32 (m, 2H), 7.45-7.50 (m, IH), 7.53-7.57 (m, IH).
As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.
Reference£º
Patent; CELGENE CORPORATION; WO2008/115516; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem