With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.
EXAMPLE 33 N-(4-methylfuro[2,3-g]quinazolin-2-yl)guanidine was made in the same manner as N-(6,7-dibutoxy-4-methyl-2-quinazolinyl)guanidine (see Example 1) except that 5-nitro-[2,3]-benzofuran was used in place of 1,2-dibutoxy-4-nitrobenzene. Name: 6,6,8-trimethyl-5,6-dihydrofuro[2,3-g]quinoline (synthesised using Method B (70% yield)). Data: 1H NMR (CDCl3) delta 7.53 (br s, 1H), 7.21 (dd, 1H, J=8.4, 0.6 Hz), 6.94 (br s, 1H), 6.51 (d, 1H, J=8.4 Hz), 5.38 (d, 1H, J=1.2 Hz), 2.29 (d, 3H, J=1.2 Hz), 1.29 (s, 6H).
The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Forray, Carlos C.; Kawakami, Joel; Konkel, Michael J.; Boteju, Lakmal W.; Wetzel, John M.; Noble, Stewart A.; Wan, Honghe; US2003/176314; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem