New learning discoveries about 18761-31-4

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18761-31-4

(a) 2,3-Dihydrobenzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (250 mg, 1.5 mmol), EtOAc (16 mL) and 10% Pd on carbon (33 mg, Aldrich). The suspension was stirred at 25 C. under 1 atm H2 for 24 h, then purged with N2, filtered through Celite and concentrated in vacuo to provide the aniline as a red-brown solid. MS (ESI, pos. ion) m/z: 136 (M+1).

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 18761-31-4

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.

EXAMPLE 33 N-(4-methylfuro[2,3-g]quinazolin-2-yl)guanidine was made in the same manner as N-(6,7-dibutoxy-4-methyl-2-quinazolinyl)guanidine (see Example 1) except that 5-nitro-[2,3]-benzofuran was used in place of 1,2-dibutoxy-4-nitrobenzene. Name: 6,6,8-trimethyl-5,6-dihydrofuro[2,3-g]quinoline (synthesised using Method B (70% yield)). Data: 1H NMR (CDCl3) delta 7.53 (br s, 1H), 7.21 (dd, 1H, J=8.4, 0.6 Hz), 6.94 (br s, 1H), 6.51 (d, 1H, J=8.4 Hz), 5.38 (d, 1H, J=1.2 Hz), 2.29 (d, 3H, J=1.2 Hz), 1.29 (s, 6H).

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Forray, Carlos C.; Kawakami, Joel; Konkel, Michael J.; Boteju, Lakmal W.; Wetzel, John M.; Noble, Stewart A.; Wan, Honghe; US2003/176314; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem