Simple exploration of 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

15832-09-4, 6-Methoxy-3(2H)-benzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product., 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.,15832-09-4

Step 4: A mixture of 6-methoxy-benzofuran-3(2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. Afterwards, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl(6-methoxy-1-benzofuran-3-yl)acetate, was obtained as a white oil. Yield: 1.8 g (76%); (M+H): 235.

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Asselin, Magda; Grosu, George Theodore; Evrard, Deborah A.; Mewshaw, Richard Eric; Meagher, Kristin; US2009/54454; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

To a solution of 2-12 (450 mg, 2.74 mmol) in anhydrous acetic acid (4.9 ml/mmol) was added the 3-chloro-4-hydroxybenzaldehyde (2.74 mmol), followed by dropwise addition of concentrated HCl (0.3 ml/mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with distilled water (100 ml) and stirred for 15 min. The precipitate formed was filtered under suction to yield aurone 6-12 which was used without further purification, yellow solid, yield 91.6%. M.p. 210-212 C, 1H NMR (DMSO-d6, 500 MHz): delta 8.0 (d,J 2 Hz, 1H), d 7.79 (dd, J1 2 Hz, J2 8.6 Hz, 1H), 7.68 (d,J 8.6 Hz, 1H), 7.17 (d, J 2 Hz, 1H), 7.08 (d, J 8.5 Hz, 1H), 6.85 (dd,J1 2.1, J2 8.5 Hz, 1H), 6.79 (s, 1H), 3.93 (s, 3H).

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liew, Kok-Fui; Chan, Kit-Lam; Lee, Chong-Yew; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 195 – 210;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 15832-09-4

15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

To a solution of 6-methoxybenzofuran-3(2H)-one (58?mg, 0.354?mmol) in MeOH (5?mL) were added an aqueous solution of KOH (50%, 0.30?mL) and 3,4-dimethoxybenzaldehyde (59?mg, 0.354?mmol), and the mixture was stirred at room temperature for 2?h. The solid was then filtered, washed with cold MeOH and dried. The crude product was recrystallized from MeOH to afford 34 (25?mg, 23%) as a yellow solid. 1H NMR (CDCl3) delta 7.72 (d, 1H, J?=?8.3?Hz), 7.51 (d, 1H, J?=?1.9?Hz), 7.48 (dd, 1H, J1?=?8.3?Hz, J2?=?1.9?Hz), 6.94 (d, 1H, J?=?8.3?Hz), 6.80 (s, 1H), 6.77 (dd, 1H, J1?=?8.3?Hz, J2?=?2.1?Hz), 6.76 (s, 1H), 3.99 (s, 3H), 3.95 (s, 3H), 3.94 (s, 3H). 13C NMR (CDCl3) delta 183.0, 168.4, 167.4, 150.8, 149.2, 147.0, 126.0, 125.9, 125.6, 115.3, 113.9, 112.6, 112.2, 111.4, 96.8, 56.3, 56.2, 56.2. IR (ATR) upsilon 1596, 1516, 1442, 1424, 1292, 1283, 1261, 1169, 1145, 1122, 1091, 1043, 1015, 949, 896, 862, 835, 816, 771, 700?cm-1. HRMS (ESI) calc. for C18H17O5 [M + H]+ 313.1071, found 313.1065.

15832-09-4 6-Methoxy-3(2H)-benzofuranone 585368, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Olleik, Hamza; Yahiaoui, Samir; Roulier, Brayan; Courvoisier-Dezord, Elise; Perrier, Josette; Peres, Basile; Hijazi, Akram; Baydoun, Elias; Raymond, Josette; Boumendjel, Ahcene; Maresca, Marc; Haudecoeur, Romain; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 133 – 141;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem