Category: 942-06-3

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.1.20 5,6-Dichlorophthalide (41) Anhydride 40 (9.53 g, 42.6 mmol) was dissolved with stirring in THF (80 mL) and the solution was cooled to 0 ¡ãC under an Ar atmosphere. NaBH4 (1.63 g, 43.1 mmol) was added slowly in a single portion, and the mixture was stirred with cooling to 0 ¡ãC for 50 min. The mixture was removed from the ice-water bath and warmed to room temperature for 17 h. MeOH (20 mL) was added slowly and cautiously to the obtained suspension. The mixture was concentrated in vacuo. Dilute, aqueous HCl (0.1 M, 24 mL) was added to the residue. After stirring the mixture for 10 min, it was filtered. The collected solids were vigorously heated at reflux in PhMe (100 mL) with pTsOH¡¤H2O (0.15 g), using a Dean-Stark trap to collect H2O, for 30 h 15 min. The mixture was concentrated in vacuo. The residue was washed with H2O (50 mL) and the solid was azeotroped with PhMe (10 mL) and dried under high vacuum to provide 41 (6.41 g, 74percent) as a white solid, Rf (SiO2, CHCl3) 0.55: mp 157-160 ¡ãC. 1H NMR (300 MHz, DMSO-d6) delta 8.14 (s, 1H), 8.04 (s, 1H), 5.40 (s, 2H); CIMS m/z (rel intensity) 203/205/207 (MH+, 100/71/14)., 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

4,5-Dichlorophthalic anhydride (430 mg, 2.0 mmol) and 4-aminobutyric acid (206 mg, 2.0 mmol) were added to glacial acetic acid (10 mL) and heated to 100 C for 3 h. The reaction was quenched with water (10 mL) and the NaOH solution (0.1 mol/L) was adjusted to pH 6-8. Dichloromethane extraction (10mL ¡Á 3), washed with saturated NaHCO3 solution, washed with water, combined with organic phase, dried over anhydrous sodium sulfateDry and dry, 576mg of yellow solid.LC-MS and 1H-NMR confirmed the expected intermediate compound in a yield of 96.0%., 942-06-3

The synthetic route of 942-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Chinese Academy Of Sciences Animal Institute; Wu Song; Zhou Qi; Zhang Wenxuan; Wu Jun; Wu Hongna; Hao Jie; Wang Liu; (88 pag.)CN109867661; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of anhydride (1 mmol), formamide (1.1 mmol for monoanhydrides and 2.2 mmol for dianhydrides) and 1 g clay was ground together in a mortar using pestle for the time described in Table 1. The reaction mixture was warmed. After completing the reaction (monitored by TLC, after observing no anhydride presence in the reaction mixture), the product was extracted by washing clay with chloroform (2¡Á15 mL), the solvent was removed under vacuum to afford the relevant N-unsubstituted cyclic imide. The solid imide was washed thoroughly with water, dried, and then recrystallized from ethanol. The solid clay portion was washed with methanol and dried at 120 ¡ãC under a reduced pressure to be reused in the subsequent reactions which showed the gradual decrease in the activity (Table 1). Isolated products were characterized by melting points, IR, 1H NMR spectrometric data and were compared with the literature or authentic samples., 942-06-3

The synthetic route of 942-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Marvi, Omid; Journal of the Chilean Chemical Society; vol. 62; 2; (2017); p. 3501 – 3504;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem