Tag: 942-06-3

Brief introduction of 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

To a solution of 5,6-dichloroisobenzofuran-1,3-dione (2 g, 9.22 mmol) in xylene (10 ml), 2-aminoacetic acid (0.761 g, 10.14 mmol) was added, and the reaction was heated at 160¡ã C. for 40 hours. The precipitate that formed during the reaction was filtered, washed with water and hexanes and dried affording 2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid (2.33 g, 8.50 mmol, 92percent yield).

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Chiesi Farmaceutici S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Capaldi, Carmelida; Carzaniga, Laura; La Porta, Elena; Guala, Matilde; US2013/102576; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

To a solution of 5, 6-dichloroisobenzofuran-1, 3-dione (8.8 g, 40.6 mmol) in acetic acid (40 mL), hydrazine (1.886 ml, 48.7 mmol) was added carefully at room temperature. The mixture was stirred at 70 ¡ãC overnight under nitrogen. The reaction mixture was cooled and the solid material was collected to give the title compound, which was used without further purification (8.9 g, 90percent). LCMS (Method B): m/z 231.7 (M+H), retention time: 1.38 minutes. ?H NIVIR (DMSO-d6, 400 IVIHz) oe 11.88 (s, 2H), 8.18 (s, 2H).

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; DAI, Yujia; MICHAELIDES, Michael; (83 pag.)WO2016/123796; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem