Day: August 19, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.588703-29-1,Methyl benzofuran-6-carboxylate,as a common compound, the synthetic route is as follows.

5.Add compounds to the reaction flask1 (5.89kg, 11.04mol, 1.0eq) and MeOH (30L),Dissolve with stirring, add 27.65% NaOH aqueous solution to the reaction solution(9L), stirred at room temperature for 1 hour, TLC analysis of raw materials was consumed.Dilute the reaction solution with 20L of water.Wash the reaction with 20L of DCM.The aqueous phase is adjusted to a pH of 2 to 3 using concentrated hydrochloric acid, and the solid content is filtered.Dry at 45 to obtain white solid compound(2.66 kg, yield: 33%).

588703-29-1 Methyl benzofuran-6-carboxylate 22481705, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Zheng Baofu; Gao Qiang; Li Shuoliang; Yang Chengwu; Ma Zhenbiao; (11 pag.)CN110684000; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part A Preparation of 5-(2,3-dihydrobenzofuranyl) sulfonyl chloride To a solution of 3.35 g of anhydrous N,N-dimethylformamide at 0 C. under nitrogen was added 6.18 g of sulfuryl chloride, whereupon a solid formed. After stirring for 15 minutes, 4.69 g of 2,3-dihydrobenzofuran was added, and the mixture heated at 100 C. for 2 hours. The reaction was cooled, poured into ice water, extracted with methylene chloride, dried over magnesium sulfate, filtered and concentrated the crude material. This was recrystallized from ethyl acetate to afford 2.45 g of 5-(2,3-dihydrobenzofuranyl)sulfonyl chloride.

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G.D. Searle & Co.; US5705500; (1998); A;; ; Patent; G.D. Searle & Co.; US5776971; (1998); A;; ; Patent; G.D. Searle & Co.; US6143788; (2000); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

Under a nitrogen stream, 5-bromobenzofuran (25 g, 0.126 mol), 4,4,4 ‘, 4,5,5,5,5-octamethyl-2,2’-bi (1,3,2-dioxaborolane) (38.67 g, 0.152 Dioxane (500 ml), and the mixture was stirred at 130 C for 12 hours. The reaction was terminated. The mixture was extracted with ethyl acetate, the water was removed with MgSO 4 and purified by column chromatography to obtain 23.23 g of benzofuran-5-yl) -4,4,5,5-etramethyl-1,3,2-dioxaborolane , Yield: 75%).

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Doosan Co., ltd; Kim, Tae Hyoung; Kim, Song Mu; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; Park, Ho Chul; (40 pag.)KR101599586; (2016); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

j0041 1j To a solution of 6-bromobenzofuran (1.0 g, 5.1 mmol) in anhydrous tetrahydrofuran (15 mL) at -78 C under nitrogen was added dropwise lithium diisopropylamide (2.0 M in n-heptane, 3.1 mL, 6.2 mmol). The mixture was stirred at at -78 C for 30mm and then hexachloroethane (1.2 g, 5.1 mmol) was added dropwise. The reaction was stirred at -78 C for another one hour, then poured into water (20 mL) and extracted with ethyl acetate (2 x 30 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography [petroleum ether: ethyl acetate = 1:01 to give compound B-70 (0.36 g, 28% yield) as a colorless oil. ?H-NMR (CD3OD, 400 MHz): 7.69 (s, 1H), 7.46 (d, J=8.0 Hz, 1H), 7.40 (dd, J1=8.4 Hz, J2=1.6 Hz, 1H), 6.77 (s, 1H).

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Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

32703-79-0, 5-(tert-Butyl)isobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of substituted benzyl amine (10 mmol) and an acid anhydride (10 mmol) in glacial acetic acid (15mL) was heated under reflux for 4h. After the evaporation of the reaction mixture to dryness under reduced pressure, the residue was neutralised by a solution of sodium bicarbonate (4%) until effervescence ceased. The precipitate obtained was washed with water, dried and re-crystallised from an appropriate solvent.

32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Alanazi, Amer M.; El-Azab, Adel S.; Al-Suwaidan, Ibrahim A.; Eltahir, Kamal Eldin H.; Asiri, Yousif A.; Abdel-Aziz, Naglaa I.; Abdel-Aziz, Alaa A.-M.; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 115 – 123;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a stirred solution of 6-bromobenzo[b]furan (100 mg, 0.507 mmol) in 1 ,4-dioxane (15 mL), tert-butyl 6-fluoro-3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-indole-1 – carboxylate (Intermediate 2, 180 mg, 0. 507 mmol), K2CO3 (210 mg, 1 .52 mmol) and Pd(dppf)CI2 (19 mg, 0.025 mmol) were added. The mixture was stirred at 80 C for 15 hrs. The solvent was removed and the residue was purified by prep-TLC (EtOAc/Petroleum Ether=1 /10) to afford 1 12.8 mg (63%) of the title compound. LC-MS for C2iH18FNO3+H+ [M+H]+ : calcd: 351 .1 ; found: 351 .8. 1 H NMR (400 MHz, CDCI3) delta [ppm]: 7.96 (d, J = 4.8 Hz, 1 H), 7.79-7.76 (m, 2H),7.71 -7.67 (m, 3H),7.50 (dd, J = 8.0 Hz,1 .6Hz, 1 H),7.06 (dd, J = 8.8, 2.4 Hz, 1 H), 6.82 (d, J = 1 .0 Hz, 1 H), 1 .70 (s, 9H).

The synthetic route of 128851-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ITEOS THERAPEUTICS; CAUWENBERGHS, Sandra; CROSIGNANI, Stefano; DRIESSENS, Gregory; DEROOSE, Frederik; (271 pag.)WO2015/140717; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

To a solution of 5,6-dichloroisobenzofuran-1,3-dione (2 g, 9.22 mmol) in xylene (10 ml), 2-aminoacetic acid (0.761 g, 10.14 mmol) was added, and the reaction was heated at 160¡ã C. for 40 hours. The precipitate that formed during the reaction was filtered, washed with water and hexanes and dried affording 2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid (2.33 g, 8.50 mmol, 92percent yield).

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Chiesi Farmaceutici S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Capaldi, Carmelida; Carzaniga, Laura; La Porta, Elena; Guala, Matilde; US2013/102576; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) was heated at reflux in SOCl2 (5?10 equiv) for 4 h at 100 ¡ãC. The remaining SOCl2 was removed in vacu-um and the obtained solid was dissolved in CH2Cl2 (10 mL). The mix-ture was cooled to 0 ¡ãC and the desired primary amine (2.0 equiv)was slowly added. The solution was stirred for 24 h at r.t. then thereaction mixture was diluted with EtOAc (70 mL), washed with citricacid (0.5 M), sat. aq Na2CO3 solution, and brine. The organic layer wasdried over MgSO4 and the solvent was removed under reduced pres-sure. The obtained products were used without further purification.

As the paragraph descriping shows that 16859-59-9 is playing an increasingly important role.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

128851-73-0, 6-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 11 (2RS,3RS)-3-benzofuran-6-yl-1-dimethylamino-2-methylpentan-3-ol Hydrochloride(10) 3.45 g (18 mmole) 6-bromobenzofurane (prepared according to EP 355 827) and 6 ml 1,2-dibromoethane, dissolved in 60 ml dry ether, were added drop-wise over 1.5 hours to 2.12 g (87 mmole) magnesium turnings in 30 ml dry ether; after the addition the mixture was heated under reflux for 30 minutes. Thereafter, 2.5 g (18 mmole) 1-dimethylamino-2-methylpentan-3-one dissolved in 7.5 ml ether was added drop-wise over 1.5 hours whilst cooling in an ice bath to maintain an internal temperature of 5-10 C. The reaction mixture was allowed to stand for 12 hours at room temperature, and was then cooled again to 5-10 C. and added to 35 ml of 20% aqueous ammonium chloride solution. After phase separation, the aqueous phase was extracted twice with 50 ml ether. The combined organic phases were dried over sodium sulphate. After removing the solvent by distillation the residue (3.9 g) was introduced on to a 5*16 cm column packed with silica gel. 0.95 g of base were obtained by elution with 7:1 diisopropyl ether/methanol, from which 0.82 g of hydrochloride (10) (15.5% theoretical) with a melting point of 162 C. were obtained with trimethylchlorosilane/water in ethyl acetate/2-butanone.

The synthetic route of 128851-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US6248737; (2001); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

This Example illustrates a process for preparing a compound of formula (IV). This Example also illustrates the conversion of a compound of formula (IV) to the hydrobromide salt.[0048] Into a reaction vessel were charged 2,2-diphenyl-2-[(35)-pyrrolidin-3- yl]acetamide L-(+)-tartrate (90.00 g, 0.21 mol), methyltriethylammonium chloride (4.82 g, 0.03 mol) and 2-methyltetrahydrofuran (180 mL). The resulting suspension was heated to 60-70 ¡ãC. To the suspension was added a solution of potassium hydroxide (69.79 g, 1.05 mol) in water (180 mL), keeping the temperature between 60 and 70 0C. The mixture was heated to reflux and to this mixture was added dropwise a solution of 5-(2-bromoethyl)-2,3- dihydro-1-benzofuran (56.98 g, 0.25 mol) in 2-methyltetrahydrofuran (270 mL). The resulting mixture was heated at reflux for 16 h and cooled to room temperature. The phases were separated and the organic phase was washed twice with 180 mL of a 10percent aqueous solution of ammonium chloride. The remaining water was distilled azeotropically and hydrobromic acid 48percent (28.19 mL) was added dropwise at room temperature. The resulting suspension was cooled to 0-5 ¡ãC, stirred at this temperature for 2 h and filtered. An almost white solid was obtained (188.0 g, l.o.d. = 48.83percent, 90.67percent yield, HPLC purity (method B): 98.96percent). This solid can be optionally dried at 60 ¡ãC under vacuum. This solid can be optionally further purified as in Example 4.[0049] The results demonstrate a process for preparing (S)-2- { 1 -[2-(2,3- dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide of formula (IV) in high yield and purity.

As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; MEDICHEM, S.A.; WO2008/29257; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem