With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.
To a stirred solution of 6-bromobenzo[b]furan (100 mg, 0.507 mmol) in 1 ,4-dioxane (15 mL), tert-butyl 6-fluoro-3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-indole-1 – carboxylate (Intermediate 2, 180 mg, 0. 507 mmol), K2CO3 (210 mg, 1 .52 mmol) and Pd(dppf)CI2 (19 mg, 0.025 mmol) were added. The mixture was stirred at 80 C for 15 hrs. The solvent was removed and the residue was purified by prep-TLC (EtOAc/Petroleum Ether=1 /10) to afford 1 12.8 mg (63%) of the title compound. LC-MS for C2iH18FNO3+H+ [M+H]+ : calcd: 351 .1 ; found: 351 .8. 1 H NMR (400 MHz, CDCI3) delta [ppm]: 7.96 (d, J = 4.8 Hz, 1 H), 7.79-7.76 (m, 2H),7.71 -7.67 (m, 3H),7.50 (dd, J = 8.0 Hz,1 .6Hz, 1 H),7.06 (dd, J = 8.8, 2.4 Hz, 1 H), 6.82 (d, J = 1 .0 Hz, 1 H), 1 .70 (s, 9H).
The synthetic route of 128851-73-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ITEOS THERAPEUTICS; CAUWENBERGHS, Sandra; CROSIGNANI, Stefano; DRIESSENS, Gregory; DEROOSE, Frederik; (271 pag.)WO2015/140717; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem