Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein was written by Wang, Tianlu;Hong, Tingting;Huang, Yue;Su, Haomiao;Wu, Fan;Chen, Yi;Wei, Lai;Huang, Wei;Hua, Xiaoluan;Xia, Yu;Xu, Jinglei;Gan, Jianhua;Yuan, Bifeng;Feng, Yuqi;Zhang, Xiaolian;Yang, Cai-Guang;Zhou, Xiang. And the article was included in Journal of the American Chemical Society in 2015.Related Products of 3326-34-9 This article mentions the following:
The FTO protein is unequivocally reported to play a critical role in human obesity and in the regulation of cellular levels of m6A modification, which makes FTO a significant and worthy subject of study. Here, we identified that fluorescein derivatives can selectively inhibit FTO demethylation, and the mechanisms behind these activities were elucidated after we determined the X-ray crystal structures of FTO/fluorescein and FTO/5-aminofluorescein. Furthermore, these inhibitors can also be applied to the direct labeling and enrichment of FTO protein combined with photoaffinity labeling assay. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Related Products of 3326-34-9).
5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Related Products of 3326-34-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem