With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.588703-29-1,Methyl benzofuran-6-carboxylate,as a common compound, the synthetic route is as follows.
5.Add compounds to the reaction flask1 (5.89kg, 11.04mol, 1.0eq) and MeOH (30L),Dissolve with stirring, add 27.65% NaOH aqueous solution to the reaction solution(9L), stirred at room temperature for 1 hour, TLC analysis of raw materials was consumed.Dilute the reaction solution with 20L of water.Wash the reaction with 20L of DCM.The aqueous phase is adjusted to a pH of 2 to 3 using concentrated hydrochloric acid, and the solid content is filtered.Dry at 45 to obtain white solid compound(2.66 kg, yield: 33%).
588703-29-1 Methyl benzofuran-6-carboxylate 22481705, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Zheng Baofu; Gao Qiang; Li Shuoliang; Yang Chengwu; Ma Zhenbiao; (11 pag.)CN110684000; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem