Simple exploration of 588703-29-1

As the paragraph descriping shows that 588703-29-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.588703-29-1,Methyl benzofuran-6-carboxylate,as a common compound, the synthetic route is as follows.

588703-29-1, [00132] The benzofuranyl carbonyl moiety was prepared by protecting the hydroxyl groupof compound 13 by reacting with tert-butyldimethylsilyl chloride (1.0 equivalents) andtriethylamine (TEA, 1.1 equivalents) in acetone, to give compound 14 in 79% yield. A solutionof compound 14 in methanol was then treated with sodium borohydride (1.0 equivalent) at roomtemperature overnight. The reaction was quenched with an addition of acetone, stirred at roomtemperature for a further 2.5 hours, aqueous HC1 (4N) was added with the temperature controlledto below 28 C, tetrahydrofuran (THF) was added, and the solution stirred overnight under argonand in the absence of light. The product, compound 15, was isolated quantitatively by extractioninto methylene chloride, concentrated at low heat, and used without further purification. Thetriflate ester, compound 16, was produced in 69% yield from compound 15 by reacting it with Nphenyl-bis(trifluoromethanesulfonimide) (1.0 equivalent) in methylene chloride for 72 hours.Compound 16 in a mixture of DMF, methanol, and triethylamine, was added to a preparedsolution of palladium acetate, 1,3-Bis(diphenylphosphino)propane (dppp), DMF and methanol inan autoclave. Carbon monoxide was charged into the autoclave to a pressure of 8 bar, and the reaction mixture was heated at 70 C for 6 hours. After workup, compound 17 was isolated in 91% yield. Lithium hydroxide (4 equivalents) in methanol and water was used to hydrolyze the ester and permit the isolation of compound 18? in 97% yield.

As the paragraph descriping shows that 588703-29-1 is playing an increasingly important role.

Reference£º
Patent; SARCODE BIOSCIENCE INC.; ZELLER, James, Robert; VENKATRAMAN, Sripathy; BROT, Elisabeth, C.A.; IYER, Subashree; HALL, Michael; WO2014/18748; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 588703-29-1

588703-29-1 Methyl benzofuran-6-carboxylate 22481705, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.588703-29-1,Methyl benzofuran-6-carboxylate,as a common compound, the synthetic route is as follows.

5.Add compounds to the reaction flask1 (5.89kg, 11.04mol, 1.0eq) and MeOH (30L),Dissolve with stirring, add 27.65% NaOH aqueous solution to the reaction solution(9L), stirred at room temperature for 1 hour, TLC analysis of raw materials was consumed.Dilute the reaction solution with 20L of water.Wash the reaction with 20L of DCM.The aqueous phase is adjusted to a pH of 2 to 3 using concentrated hydrochloric acid, and the solid content is filtered.Dry at 45 to obtain white solid compound(2.66 kg, yield: 33%).

588703-29-1 Methyl benzofuran-6-carboxylate 22481705, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Zheng Baofu; Gao Qiang; Li Shuoliang; Yang Chengwu; Ma Zhenbiao; (11 pag.)CN110684000; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem