With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.,127264-14-6
The compound (3S) -pyrrolidin-3-yl cyclopentyl (hydroxy) phenylacetate (0.2 g, 0.69 MM) was dissolved in acetonitrile (5.0 ml) followed by the addition of 5- (2-bromoethyl)-2, 3- DIHYDRO-1-BENZOFURAN (0.173 g, 0.76 mM), potassium carbonate (0.29 g, 2.01 MM) and potassium iodide (0.23 g, 1.38 mM). The reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution followed by drying over anhydrous sodium sulphate. The residue was purified by silica get column chromatography using 10percent methanol in chloroform to get the title compound as oil. Yield = 50percent (0. 15 G, 0. 34 MM). 1H NMR (CDCl3) : delta 7.66 (d, J = 7 Hz, 2H), 7.31-7.36 (M, 3H), 7.03 (d, J = 8 Hz, 1H), 6.93 (t, J = 8 Hz, 1H), 6.69-6.72 (M, 1H), 5.22-5.24 (M, 1H), 4.55 (t, J = 9 Hz, 2H), 3.76 (br M, 1H), 3.18 (t, J = 9 Hz, 2H), 2.54-2.92 (M, 8H), 2.00-2.50 (M, 1H), 1.25-1.63 (M, 1 OH, including-OH).
The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.