Tag: 127264-14-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.,127264-14-6

The compound (3S) -pyrrolidin-3-yl cyclopentyl (hydroxy) phenylacetate (0.2 g, 0.69 MM) was dissolved in acetonitrile (5.0 ml) followed by the addition of 5- (2-bromoethyl)-2, 3- DIHYDRO-1-BENZOFURAN (0.173 g, 0.76 mM), potassium carbonate (0.29 g, 2.01 MM) and potassium iodide (0.23 g, 1.38 mM). The reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution followed by drying over anhydrous sodium sulphate. The residue was purified by silica get column chromatography using 10percent methanol in chloroform to get the title compound as oil. Yield = 50percent (0. 15 G, 0. 34 MM). 1H NMR (CDCl3) : delta 7.66 (d, J = 7 Hz, 2H), 7.31-7.36 (M, 3H), 7.03 (d, J = 8 Hz, 1H), 6.93 (t, J = 8 Hz, 1H), 6.69-6.72 (M, 1H), 5.22-5.24 (M, 1H), 4.55 (t, J = 9 Hz, 2H), 3.76 (br M, 1H), 3.18 (t, J = 9 Hz, 2H), 2.54-2.92 (M, 8H), 2.00-2.50 (M, 1H), 1.25-1.63 (M, 1 OH, including-OH).

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2004/56767; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

This Example illustrates a process for preparing a compound of formula (IV). This Example also illustrates the conversion of a compound of formula (IV) to the hydrobromide salt.[0048] Into a reaction vessel were charged 2,2-diphenyl-2-[(35)-pyrrolidin-3- yl]acetamide L-(+)-tartrate (90.00 g, 0.21 mol), methyltriethylammonium chloride (4.82 g, 0.03 mol) and 2-methyltetrahydrofuran (180 mL). The resulting suspension was heated to 60-70 ¡ãC. To the suspension was added a solution of potassium hydroxide (69.79 g, 1.05 mol) in water (180 mL), keeping the temperature between 60 and 70 0C. The mixture was heated to reflux and to this mixture was added dropwise a solution of 5-(2-bromoethyl)-2,3- dihydro-1-benzofuran (56.98 g, 0.25 mol) in 2-methyltetrahydrofuran (270 mL). The resulting mixture was heated at reflux for 16 h and cooled to room temperature. The phases were separated and the organic phase was washed twice with 180 mL of a 10percent aqueous solution of ammonium chloride. The remaining water was distilled azeotropically and hydrobromic acid 48percent (28.19 mL) was added dropwise at room temperature. The resulting suspension was cooled to 0-5 ¡ãC, stirred at this temperature for 2 h and filtered. An almost white solid was obtained (188.0 g, l.o.d. = 48.83percent, 90.67percent yield, HPLC purity (method B): 98.96percent). This solid can be optionally dried at 60 ¡ãC under vacuum. This solid can be optionally further purified as in Example 4.[0049] The results demonstrate a process for preparing (S)-2- { 1 -[2-(2,3- dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide of formula (IV) in high yield and purity.

As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; MEDICHEM, S.A.; WO2008/29257; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem