With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61090-37-7,2,3-Dihydrobenzofuran-4-amine,as a common compound, the synthetic route is as follows.
Place 4-amino-2,3-dihydrobenzofuran (405 mg, 3.0 mmol) in a round bottom flask,Concentrated sulfuric acid (450 muL, 8.3 mmol.) And 6.0 mL of deionized water were added to dissolve, and the reaction system was cooled in an ice-salt bath. A deionized aqueous solution of sodium nitrite (242.2 mg of sodium nitrite in 1.5 mL of deionized water, 3.5 mmol.) Was added dropwise to the system. The solution turned red. The reaction was stirred at 0 C for 30 minutes. After adding 3.0 mL of ether, a deionized aqueous solution of potassium iodide (2.0 g of potassium iodide in 1.5 mL of deionized water, 12 mmol.) Was added dropwise, and stirred for 3 hours. After the reaction was completed, a saturated sodium thiosulfate solution was added and extracted three times with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to obtain a crude product.The crude product was subjected to petroleum ether column chromatography to obtain 518 mg of a relatively pure white 4-iodo-2,3-dihydrobenzofuran solid product in a yield of 70%.
As the paragraph descriping shows that 61090-37-7 is playing an increasingly important role.
Reference£º
Patent; Wuhan University; Zhou Qianghui; Gao Shijun; Qian Guangyin; (10 pag.)CN110483456; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem