With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13414-56-7,2,3-Dihydrobenzofuran-7-amine,as a common compound, the synthetic route is as follows.
7-Aminobenzo-2,3-dihydrofuran (3 g, 22.22 mmol) was dissolved in N, N-dimethylformamide (7 mL) and thereaction solution was cooled to 0C. A solution of N-bromosuccinimide (3.93 g, 22.22 mmol) in N,N-dimethylformamide(7 mL) was then added dropwise to the above solution over 30 minutes. After the addition, stirring was continued for 30minutes. The reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (100 mL). The organicphase was washed with saturated sodium chloride solution (50 mL 3 2), dried over anhydrous sodium sulfate, filtered,and the filtrate was concentrated under reduced pressure. And the residue was purified by silica gel column chromatography(petroleum ether: ethyl acetate = 10: 1) to deliver a yellow solid15-d (2.5 g, yield: 53%).LC-MS (ESI): m/z =214 (M+H)+
As the paragraph descriping shows that 13414-56-7 is playing an increasingly important role.
Reference£º
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; ZHANG, Nong; XU, Zusheng; WANG, Tinghan; WANG, Yuguang; (99 pag.)EP3287463; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem