Hansen, Marvin M. et al. published their research in Synlett in 2004 | CAS: 253429-31-1

7-Bromo-4-fluorobenzofuran (cas: 253429-31-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 253429-31-1

Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration was written by Hansen, Marvin M.;Clayton, Marcella T.;Godfrey, Alexander G.;Grutsch, John L. Jr.;Keast, Sandra S.;Kohlman, Dan T.;McSpadden, Andreea R.;Pedersen, Steven W.;Ward, Jeffrey A.;Xu, Yao-Chang. And the article was included in Synlett in 2004.Product Details of 253429-31-1 This article mentions the following:

2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprotection is conveniently achieved under acidic conditions. Direct C-7 metalation of benzothiophene is enabled by 2-triisopropylsilyl protection at C-2. In the experiment, the researchers used many compounds, for example, 7-Bromo-4-fluorobenzofuran (cas: 253429-31-1Product Details of 253429-31-1).

7-Bromo-4-fluorobenzofuran (cas: 253429-31-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 253429-31-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

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The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4?, R5, R5?, and R12 are as described in the specification.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3639O – PubChem

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The present invention provides the compounds of the following formula (I): and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT 1A receptor and antagonizing the 5-HT 2A receptor which comprises administering to a subject in need of such treatment an effective amount of formula (I).

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3645O – PubChem

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The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT 1A receptor and antagonizing the 5-HT 2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3643O – PubChem

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HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have identified direct acting antivirals which have significantly improved cure rates in patients. Current efforts are directed towards identification of novel direct acting antiviral targeting different mechanism of actions which could become part of all oral therapies. We recently disclosed the identification of a novel tricyclic indole derived inhibitors of HCV NS5B polymerase that bound to the enzyme close to the active site. In this manuscript we describe further optimization of potency and pharmacokinetics (PK) of these inhibitors to identify compounds in low nM potency against gt-1b. These analogs also demonstrate excellent PK in rats and monkeys when administered as a dimethyl ethyl amino ester prodrug.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3649O – PubChem

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Application of 253429-31-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.253429-31-1, Name is 7-Bromo-4-fluorobenzofuran, molecular formula is C8H4BrFO. In a article,once mentioned of 253429-31-1

The invention relates to a kind of formula (I) of the structure shown in Figure 1, 3 – disubstituted compound ketenes and its application. The compounds mainly activated PPAR alpha, to the PPPA delta and PPPA gamma have agonistic activity. Can be used for the treatment of PPAR regulating abnormal various diseases associated, such as non-alcoholic fatty liver disease particularly in the treatment of non-alcoholic hepatitis, also used for the treatment of diabetes, obesity, fibrotic diseases, cardiovascular disease (including heart failure and atherosclerosis and the like), kidney disease (including chronic renal disease and renal failure and the like), cerebral degenerative diseases (including Alzheimer’s disease and the like) such as the potential of the, has great application value. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3641O – PubChem

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The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3” (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3” represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5” (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5” represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3646O – PubChem

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The present invention provides the compounds of the following formula:Wherein the variables are as defined in the specification and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT 1A receptor and antagonizing the 5-HT 2A receptor which comprises administering to a subject in need of such treatment an effective amount of the compound of above formula.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3644O – PubChem

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4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS

The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3642O – PubChem

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TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3647O – PubChem