253429-31-1 | Page 2 of 2 | Heterocyclic Building Block-benzofuran

Some scientific research about 253429-31-1

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 253429-31-1, help many people in the next few years.HPLC of Formula: C8H4BrFO

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C8H4BrFO, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 253429-31-1, name is 7-Bromo-4-fluorobenzofuran. In an article£¬Which mentioned a new discovery about 253429-31-1

Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration

2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprotection is conveniently achieved under acidic conditions. Direct C-7 metalation of benzothiophene is enabled by 2-triisopropylsilyl protection at C-2.

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3648O – PubChem

Downstream synthetic route of 253429-31-1

As the paragraph descriping shows that 253429-31-1 is playing an increasingly important role.

253429-31-1, 7-Bromo-4-fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 57 A mixture of 7-bromo-4-fluoro-1-benzofuran (5.30 g), zinc cyanide (1.74 g), tetrakis(triphenylphosphine)palladium(0) (2.85 g), and N,N-dimethylformamide (160 mL) was stirred at 100C for 2.5 hours under argon atmosphere. After cooling to room temperature, the reactant was poured into water and extracted with ethyl acetate. Insolubles were filtered off using celite. The organic layer was washed with brine, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain 4-fluoro-1-benzofuran-7-carbonitrile (3.63 g). 1H-NMR (300 MHz, CDCl3) delta: 6.96 (1H, d, J=2.4 Hz), 7.03 (1H, d, J=8.7 Hz), 7.60 (1H, dd, J=8.7 and 5.1 Hz), 7.74 (1H, d, J=2.4 Hz). IR (KBr) 2232, 1497, 1271 cm-1, 253429-31-1

As the paragraph descriping shows that 253429-31-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1553074; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 253429-31-1

The synthetic route of 253429-31-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253429-31-1,7-Bromo-4-fluorobenzofuran,as a common compound, the synthetic route is as follows.,253429-31-1

Step C- Synthesis of Compound 16D; A solution of compound 16C (124.12 g, 577.25 mmol) in ether (2.0 L) was cooled to – 78 0C and treated dropwise with a solution of 2.5 M of n-butyllithium in hexane (235.5 mL) and allowed to stir at -78 C for 15 minutes. To this reaction mixture was added DMF (89.393 mL, 1.15 mol) and allowed to stir at -78 C for 30 minutes. The reaction mixture was quenched with methanol (23.383 mL, 577.25 mmol) and warmed to room temperature. The reaction mixture was diluted with ether (300 mL) and the organic layer was washed with water (300 mL). The separated organic layer was dried (MgSO4) filtered, concentrated in vacuo to provide compound 16D (89.00 g, 93.9%).

The synthetic route of 253429-31-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2009/32123; (2009); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem