With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.,84594-78-5
A suspension of 6-nitro-2,3-dihydrobenzofuran-5-amine [CAS 84594-78-5] (135.00g, 749.33 mmol) in concentrated HCI (250 mL) was heated to 100C for 10 mm.The solution was cooled to 0C. A solution of NaNO2 (62.04 g, 899.20 mmol) inH20 (250 mL) was added dropwise. The reaction mixture was stirred for 30 mm at0C. The reaction mixture was added slowly to a cooled (0C) solution of KI(186.58 g, 1.12 mol) in H20 (250 mL). The resulting mixture was heated to 70C for 2 h. After cooling to room temperature, H20 (2 L) was added and the crude product was extracted with EtOAc (2x 2 L). The combined organic phases were washed with aqueous HCI (10%, 1 L), aqueous NaOH (1 N, 1 L), a saturated aqueous Na2SO3 solution (1 L) and brine (1 L). After drying over MgSO4, the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: petroleum ether/EtOAc 8/1) to give5-iodo-6-nitro-2,3-dihydrobenzofuran 7a (90.00 g) as a pale yellow solid.
As the paragraph descriping shows that 84594-78-5 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee Alice Marie-Eve; BONFANTI, Jean-Francois; COESEMANS, Erwin; KESTELEYN, Bart Rudolf Romanie; MARCHAND, Arnaud Didier M; RABOISSON, Pierre Jean-Marie Bernard; (96 pag.)WO2017/167952; (2017); A1;,
Benzofuran – Wikipedia
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