Category: 84594-78-5

23-Sep-2021 News Extracurricular laboratory:new discovery of 84594-78-5

If you are interested in 84594-78-5, you can contact me at any time and look forward to more communication. Quality Control of 6-Nitro-2,3-dihydrobenzofuran-5-amine

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 6-Nitro-2,3-dihydrobenzofuran-5-amine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 84594-78-5

Benzofuran derivatives of the formula STR1 wherein V is hydrogen or acetyl, X is oxo or two hydrogen atoms, R1 and R2 each independently is hydrogen, fluorine, or chlorine, and –A–B– is –O–CH2 — or –CH2 –O–, possess valuable pharmacological properties.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2898O – PubChem

Sep-9 News Archives for Chemistry Experiments of 84594-78-5

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 84594-78-5. In my other articles, you can also check out more blogs about 84594-78-5

Electric Literature of 84594-78-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 84594-78-5, Name is 6-Nitro-2,3-dihydrobenzofuran-5-amine, molecular formula is C8H8N2O3. In a Patent，once mentioned of 84594-78-5

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I):wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 84594-78-5. In my other articles, you can also check out more blogs about 84594-78-5

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2897O – PubChem

More research is needed about 84594-78-5

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 84594-78-5, and how the biochemistry of the body works.Application of 84594-78-5

Application of 84594-78-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.84594-78-5, Name is 6-Nitro-2,3-dihydrobenzofuran-5-amine, molecular formula is C8H8N2O3. In a Patent，once mentioned of 84594-78-5

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2895O – PubChem

Final Thoughts on Chemistry for 6-Nitro-2,3-dihydrobenzofuran-5-amine

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 84594-78-5, and how the biochemistry of the body works.Related Products of 84594-78-5

Related Products of 84594-78-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 84594-78-5, Name is 6-Nitro-2,3-dihydrobenzofuran-5-amine,introducing its new discovery.

The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R1, R2, R3, R4, R5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2894O – PubChem

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In an effort to design inhibitors of human glutaminyl cyclase (QC), we have synthesized a library of N-aryl N-(5-methyl-1H-imidazol-1-yl)propyl thioureas and investigated the contribution of the aryl region of these compounds to their structure-activity relationships as cyclase inhibitors. Our design was guided by the proposed binding mode of the preferred substrate for the cyclase. In this series, compound 52 was identified as the most potent QC inhibitor with an IC50 value of 58 nM, which was two-fold more potent than the previously reported lead 2. Compound 52 is a most promising candidate for future evaluation to monitor its ability to reduce the formation of pGlu-Abeta and Abeta plaques in cells and transgenic animals.

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Reference：
Benzofuran – Wikipedia,
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In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting. Based on a combination approach, a series of 4-benzyl-4-(dimethylamino)piperidinyl analogues were designed, synthesized and evaluated for their receptor activities. Among them, compound 49 exhibited the most promising dual-acting activity toward TRPV1 and the mu-opioid receptor in vitro. In vivo, 49 displayed potent, dose-dependent antinociceptive activity in both the 1st and 2nd phases in the formalin assay. Consistent with its postulated mechanism, we confirmed that in vivo, as in vitro, compound 49 both antagonized TRPV1 and functioned as a mu-opioid agonist. This result indicates that dual-acting TRPV1 antagonist/mu-opioid ligands can be made and represent a new and promising class of analgesic.

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Benzofuran – Wikipedia,
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Reference of 84594-78-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.84594-78-5, Name is 6-Nitro-2,3-dihydrobenzofuran-5-amine, molecular formula is C8H8N2O3. In a Patent£¬once mentioned of 84594-78-5

SUBSTITUTED INDOLE COMPOUND DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS

The present invention concerns substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2893O – PubChem

Downstream synthetic route of 84594-78-5

The synthetic route of 84594-78-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

6,7-Dihydrofuro[3,2-g][1,2,4]benzotrazin-3-amine 1 -Oxide (195). A mixture of nitroaniline 194 (7.27 g, 40.4 mmol) and cyanamide (6.79 g, 162 mmol) were mixed together at 100 C, cooled to 50 0C, cHCI (15 mL) added carefully and the mixture heated at 100 0C for 4 h. The mixture was cooled to 50 C, 7.5 M NaOH solution added until the mixture was strongly basic and the mixture stirred at 100 0C for 3 h. The mixture was cooled, diluted with water (200 mL), filtered, washed with water (3 x 50 mL) and dried. EPO The aqueous fraction was extracted with CHCI3 (3 x 50 mL), dried and the solvent evaporated. The combined solids were purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give crude amine 195 (1.87 g, 23%) as a yellow powder: mp (MeOH/DCM) 241-246 0C. Anal, calcd for C9H8N4O2: C, 52.9; H, 4.0; N1 27.4. Found: C, 53.3; H, 3.8; N, 26.4%., 84594-78-5

The synthetic route of 84594-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

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As the paragraph descriping shows that 84594-78-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

84594-78-5, Preparation of 6-nitro-2,3-dihydrobenzofuran Into a 2000 mL 3-necked round-bottom flask, was placed a solution of 6-nitro-2,3-dihydrobenzofuran-5-amine (57 g, 300.83 mmol, 1.00 equiv, 95%) in H20 (1000 mL). To the mixture was added con H2SO4 (570 mL). To the above was added NaNO2 (24 g, 347.83 mmol, 1.10 equiv) in several batches, while cooling to a temperature of 0 C. To the above was added phosphenous acid (114 mL, 50%) dropwise with stirring, while cooling to a temperature of 0 C. The resulting solution was allowed to react, with stirring, for 1 h while the temperature was maintained at 45 C. in a bath of oil. The reaction progress was monitored by TLC (EtOAc/PE=1:2). The resulting solution was extracted two times with 200 mL of EtOAc and the organic layers combined. The resulting mixture was washed 2 times with 150 mL of water. The mixture was dried over Na2SO4 and concentrated by evaporation under vacuum using a rotary evaporator. The residue was purified by eluding through a column with a 1:50 EtOAc/PE solvent system. This resulted in 42 g (76%) of 6-nitro-2,3-dihydrobenzofuran as a red yellow solid.

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Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; US2008/200471; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 84594-78-5

84594-78-5 6-Nitro-2,3-dihydrobenzofuran-5-amine 13069187, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

84594-78-5, Isoamylnitrite (3 equiv) was added dropwise to a solution of 13 or 14(1 equiv) in anhydrous THF at 0C. The reaction mixture was stirred at 0C for 15 min and then refluxed for 3 h. The solution was cooled to room temperature, water (50 mL) was added, and the solution was extracted with ethyl acetate (350 mL). The organic layer was washed with brine, dried over MgSO4, then evaporated and purified by column chromatography with a gradient eluent of EA/n-hexane (2-8%) to give 15 (70%) as a yellow solid or 16 (74%) as a yellow solid.

84594-78-5 6-Nitro-2,3-dihydrobenzofuran-5-amine 13069187, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun; Bioorganic and Medicinal Chemistry; vol. 21; 13; (2013); p. 3821 – 3830;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem