Tag: 10242-12-3

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10242-12-3

Compound 69 (2.0 g, 9.66 mmol) and beta-alanine methylester¡¤HCl (1.752 g, 12.55 mmol) weredissolved in dimethylformamide (48.3 mL). 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(2.41 g, 12.55 mmol) and 4-dimethylaminopyridine (0.59 g, 4.83 mmol) were added and thereaction was stirred under Ar at room temperature for 2 d. An additional amount of beta-alaninemethylester¡¤HCl (337 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (462 mg), and 4-dimethylaminopyridine (147 mg) were added and stirred for an additional night. The reaction wascooled in an ice bath and then water was added to precipitate the desired compound. The solutionwas filtered to obtain compound 70 (2.82 g, 100% yield), which used without further purification.

As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Article; Reid, Emily E.; Archer, Katie E.; Shizuka, Manami; McShea, Molly A.; Maloney, Erin K.; Ab, Olga; Lanieri, Leanne; Wilhelm, Alan; Ponte, Jose F.; Yoder, Nicholas C.; Chari, Ravi V.J.; Miller, Michael L.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 17; (2019); p. 2455 – 2458;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.,10242-12-3

(d). 5-Nitrobenzofuran. To a 100 mL round-bottomed flask was added 5-nitrobenzo[b]furan-2-carboxylic acid, Example 38(c), (860 mg, 4.2 mmol), copper (830 mg, 13 mmol, Aldrich), and quinoline (38 mL, Aldrich). The reaction flask was placed in a 185 C. oil bath and magnetically stirred for 20 min under N2. After allowing to cool to 25 C., the mixture was filtered through a 1″ pad of Celite. To the filtrate was added 10% aq. HCl (300 mL) and the aqueous layer was extracted with Et2O (3*100 mL). The combined ethereal layers were washed with 10% HCl (4*200 mL, 1*100 mL), satd NaHCO3 (200 mL), and satd NaCl (100 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (10:0.25 hexanes:EtOAc) provided 5-nitrobenzofuran as a white solid.

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 177 (342 mg, 1.649 mmol) and compound 175 (287 mg, 1.269 mmol) were dissolved in DMF (10 mL). EDC (316 mg, 1.649 mmol) and DMAP (77 mg, 0.634 mmol) were added and the reaction was stirred under Ar at rt overnight. The crude reaction mixture was directly purified by silica gel chromatography to yield compound 178 (63 mg, 12% yield). LCMS = 4.74 mm (8 mm method). Mass observed (ESI): 415.9 (M+H). ?H NMR (400 MHz, DMSO-d6): 2.60 (t, J= 6.7 Hz, 2H), 3.50 (q, J= 6.5 Hz, 2H), 3.62 (s, 3H), 3.97 (s, 3H), 7.62 (s, 1H), 7.96 (d, J= 9.1 Hz, 1H), 8.02 (t, J= 6.1 Hz, 1H), 8.07 (s, 1H), 8.35 (dd, J= 9.1, 2.5 Hz, 1H), 8.83 (d, J= 2.4 Hz, 1H), 11.30 (s, 1H).

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem