10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 177 (342 mg, 1.649 mmol) and compound 175 (287 mg, 1.269 mmol) were dissolved in DMF (10 mL). EDC (316 mg, 1.649 mmol) and DMAP (77 mg, 0.634 mmol) were added and the reaction was stirred under Ar at rt overnight. The crude reaction mixture was directly purified by silica gel chromatography to yield compound 178 (63 mg, 12% yield). LCMS = 4.74 mm (8 mm method). Mass observed (ESI): 415.9 (M+H). ?H NMR (400 MHz, DMSO-d6): 2.60 (t, J= 6.7 Hz, 2H), 3.50 (q, J= 6.5 Hz, 2H), 3.62 (s, 3H), 3.97 (s, 3H), 7.62 (s, 1H), 7.96 (d, J= 9.1 Hz, 1H), 8.02 (t, J= 6.1 Hz, 1H), 8.07 (s, 1H), 8.35 (dd, J= 9.1, 2.5 Hz, 1H), 8.83 (d, J= 2.4 Hz, 1H), 11.30 (s, 1H).
The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem