New learning discoveries about 18761-31-4

18761-31-4, The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.

(a) 2,3-Dihydrobenzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (250 mg, 1.5 mmol), EtOAc (16 mL) and 10percent Pd on carbon (33 mg, Aldrich). The suspension was stirred at 25¡ã C. under 1 atm H2 for 24 h, then purged with N2, filtered through Celite and concentrated in vacuo to provide the aniline as a red-brown solid. MS (ESI, pos. ion) m/z: 136 (M+1).

18761-31-4, The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Further purification by column chromatography on silica gel (eluted with ethyl acetate/heptane 3:1) yielded 3.2 g of pure 5-nitro-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran which crystallized upon standing. Mp: 108-114 C. 5-Amino-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran: To a solution of all of the 5-nitrobenzofuran in 90% ethanol (50 ml) kept at reflux were added small portions of Fe powder (in total 2.5 g) and concentrated HCl (in total 0.1 ml) during 10 min. The mixture was refluxed for another hour. The inorganic precipitates were filtered off and the mixture was poured onto brine and ethyl acetate (250 ml). work-up of the organic phase afforded 1 g of crystalline 5-aminobenzofuran derivative., 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

Reference£º
Patent; H. Lundbeck A/S; US5807889; (1998); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 101 ; 2, 3-Dihvdro-benzofuran-5-vlamine; The product of preparation 100 (5. 0g, 31mmol) and 10percent Pd/C (1.25g) was added to ethanol (100mL) and the mixture was stirred under 55psi of hydrogen gas for 5 hours. The reaction mixture was then filtered through Celite and the filtrate was concentrated in vacuo to afford the title product as a pale brown powder in 92percent yield. MS ES+ m/z 135 [M+]. m. p. 73-77¡ãC, 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 18761-31-4

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18761-31-4

(a) 2,3-Dihydrobenzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (250 mg, 1.5 mmol), EtOAc (16 mL) and 10% Pd on carbon (33 mg, Aldrich). The suspension was stirred at 25 C. under 1 atm H2 for 24 h, then purged with N2, filtered through Celite and concentrated in vacuo to provide the aniline as a red-brown solid. MS (ESI, pos. ion) m/z: 136 (M+1).

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 18761-31-4

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18761-31-4,5-Nitrobenzofuran,as a common compound, the synthetic route is as follows.

EXAMPLE 33 N-(4-methylfuro[2,3-g]quinazolin-2-yl)guanidine was made in the same manner as N-(6,7-dibutoxy-4-methyl-2-quinazolinyl)guanidine (see Example 1) except that 5-nitro-[2,3]-benzofuran was used in place of 1,2-dibutoxy-4-nitrobenzene. Name: 6,6,8-trimethyl-5,6-dihydrofuro[2,3-g]quinoline (synthesised using Method B (70% yield)). Data: 1H NMR (CDCl3) delta 7.53 (br s, 1H), 7.21 (dd, 1H, J=8.4, 0.6 Hz), 6.94 (br s, 1H), 6.51 (d, 1H, J=8.4 Hz), 5.38 (d, 1H, J=1.2 Hz), 2.29 (d, 3H, J=1.2 Hz), 1.29 (s, 6H).

The synthetic route of 18761-31-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Forray, Carlos C.; Kawakami, Joel; Konkel, Michael J.; Boteju, Lakmal W.; Wetzel, John M.; Noble, Stewart A.; Wan, Honghe; US2003/176314; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem